Romanian Journal of Oral Rehabilitation Vol. 12, No. 1, January - March 2020 142 PLATELET DERIVATIVES WITH DENTAL MEDICINE APPLICATIONS Hurjui Ion 1 , Delianu Carmen 1 , Hurjui Loredana Liliana 1* , Jipu Raluca 1 Mitrea Mihaela 1* , Balcoș Carina 2 , Armencia Adina Oana 2 , Mârțu Maria Alexandra 2 , Grădinaru Irina 2 “Grigore T. Popa”, University of Medicine and Pharmacy Iasi, Romania 1 Faculty of Medicine 2 Faculty of Dental Medicine Corresponding author: *Loredana Liliana Hurjui e-mail: loredana.hurjui@umfiasi.ro *Mihaela Mitrea e-mail: mihaela.mitrea77@gmail.com ABSTRACT The role of platelets is to trigger the inflammatory response which, in turn, will trigger the presence of tissue growth factors that will be involved in the tissue repair process. Platelet rich plasma (PRP) is a concentrate used for therapeutic purposes which has become increasingly used by treating various dermatological pathologies, musculoskeletal disorders and not least with increasingly frequent indications in the pathology of the oro-dento- maxillare sphere, as a consequence of its potential to repair tissues with reduced regeneration capacity and apparent harmlessness. PRP is defined as a plasma preparation with a higher platelet content than found in the blood flow of a healthy individual (200 000 per microliter) typically 5 times higher. This study in the literature aims to review the biological basis of PRP, its preparation and processing for its use as well as its main applications. At the same time, another derivative of practical importance in dental medicine, PRF (plateled rich fibrin), is presented. PRF is a second-generation PRP thrombocyte concentrate, which provides the implant dentist with access to growth factors through a simple and up-to-date technology. These growth factors are autologous, non-toxic and non-immunogenic, increasing and accelerating normal bone regeneration pathways. Key words: Platelet rich plasma, plateled rich fibrin, dental medicine. INTRODUCTION PRP is a new approach to tissue regeneration and becomes a valuable help to promote healing in many dental and oral surgery procedures, especially in elderly patients, with a hight impact in the improving the quality of life [1]. PRP originates from the centrifugation of the patient's own blood and contains growth factors that influence wound healing, thus playing an important role in tissue repair mechanisms. Since its inception, in the 1980s and 1990s, when it was first used in cardiac and maxillofacial surgery, it has reached new uses in recent years in dental medicine, facial aesthetics, dermatology, sports medicine for tendon management pathology, muscle, ligament and cartilaginous lesions. PRF is considered an autologous healing material. In the fibrin matrix, there are leukocytes, platelets and most of the cells that act in the tissue healing process. In this review will analyze the clinical and biological features of PRF action recorded in bone regeneration in the field of oral