Thakare et al Journal of Drug Delivery & Therapeutics. 2019; 9(4-A):415-424 ISSN: 2250-1177 [415] CODEN (USA): JDDTAO Available online on 30.08.2019 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Research Article Formulation and Evaluation of Mucoadhesive Buccal Tablet of Repaglinide Thakare Eknath B * ., Malpure Prashant S., Maru Avish D., More Yashpal M. Department of Pharmaceutics, Loknete Dr. J.D. Pawar College of Pharmacy, Manur, Tal-Kalwan, Dist-Nashik (Maharashtra) 423501 ABSTRACT The aim of present investigation was formulation and evaluation of mucoadhesive buccal tablet of Repaglinide to study the effect of different polymers on release profile of drug for prolonged release. In this study mucoadhesive buccal tablet were prepared by direct compression method. Various rheological characteristics of the powder bed like bulk density, compressibility index, and angle of repose were evaluated and studied. Mucoadhesive buccal tablets were compressed on a 8 station mini press using 10 mm flat faced punches and were all assessed for weight variation, hardness, thickness, percent swelling index, mucoadhesive strength and in vitro release of the drug by using USP TDT 08L dissolution testing apparatus method II using a paddle at 50 rpm. Data was optimized by using 3 2 full factorial design by using software named as design expert and with the help of kinetic study. The stability studies showed that there is no decrease in the drug content of all formulations for the period of 2 months. Keywords: Buccal tablet, Repaglinide, HPMC K100M, Xanthan gum. Article Info: Received 10 July 2019; Review Completed 17 Aug 2019; Accepted 23 Aug 2019; Available online 30 Aug 2019 Cite this article as: Thakare EB., Malpure PS., Maru AD., More YM, Formulation and Evaluation of Mucoadhesive Buccal Tablet of Repaglinide, Journal of Drug Delivery and Therapeutics. 2019; 9(4-A):415-424 http://dx.doi.org/10.22270/jddt.v9i4-A.3488 *Address for Correspondence: Mr. Thakare Eknath B., Department of Pharmaceutics, Loknete Dr. J.D. Pawar College of Pharmacy, Manur, Tal-Kalwan, Dist-Nashik (Maharashtra) 423501 INTRODUCTION Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere biological surface for an extended period of time. Among the various routes of drug delivery the oral route is perhaps the most preferred by patients and clinicians alike. However, peroral administration of drugs has disadvantages, such as hepatic first-pass metabolism and enzymatic degradation within the gastrointestinal (GI) tract, that prohibit oral administration of certain classes of drugs, especially peptides and proteins. Consequently, other absorptive mucosas are considered as potential sites for drug administration. Transmucosal routes of drug delivery (i.e., the mucosal linings of the nasal, rectal, vaginal, ocular, and oral cavities) offer distinct advantages over peroral administration for systemic effect. These advantages include possible bypass of first-pass effects and avoidance of presystemic elimination within the GI tract. The buccal region of oral cavity is an attractive site for the delivery of drugs owing to the ease of the administration. Buccal drug delivery involves the administration of desired drug through the buccal mucosal membrane lining of the oral cavity. This route is useful for mucosal (local effect) and trans-mucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, where as the second case involves drug absorption through the mucosal barrier to reach the systemic circulation. Mucoadhesive drug delivery systems Mucoadhesive drug delivery systems are delivery systems, which utilized the property of bioadhesion of certain polymers, which become adhesive on hydration and hence can be used for targeting a drug to particular region of the body for extended period of time. The ability to maintain a delivery system at a particular location for an extended period of time has great appeal for both local as well as systemic drug bioavailability. Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because it provides the possibility of avoiding either destruction by gastrointestinal contents or hepatic first-pass in activation of drug. MATERIALS &METHODS Materials Repaglinide was provided as sample from Swapnroop Laboratories Aurangabad. HPMC K100M, Chitosan, dextrose, mannitol, ethyl cellulose.