The Internet Journal of Gynecology and Obstetrics ISSN: 1528-8439 Evaluation Of The Efficacy And Tolerability Of Micronutrient Supplementation In Treatment Of Post Menopausal Symptoms Suchitra Pandit Professor, Department of Gynecology & Obstetrics, LTM Medical College and General Hospital Mumbai India Shahikant Umbardand Senior Resident, Department of Gynecology & Obstetrics, LTM Medical College and General Hospital Mumbai India V. B Ghodake Senior Resident, Department of Gynecology & Obstetrics, LTM Medical College and General Hospital Mumbai India Urvashi Vats Senior Resident, Department of Gynecology & Obstetrics, LTM Medical College and General Hospital Mumbai India Himanshu Tayade Manager, Department of Medical Services, Meyer Organics Pvt. Ltd Onkar Rathod Assistant Manager, Department of Medical Services, Meyer Organics Pvt. Ltd Citation: S. Pandit , S. Umbardand, V.B. Ghodake , U. Vats , H. Tayade , O. Rathod : Evaluation Of The Efficacy And Tolerability Of Micronutrient Supplementation In Treatment Of Post Menopausal Symptoms. The Internet Journal of Gynecology and Obstetrics. 2012 Volume 16 Issue 1 Keywords: Micronutrients, Nutritional supplementation, Menopausal symptoms Abstract Objective- To study the efficacy and tolerability of micronutrient supplementation in alleviating menopausal symptomsMethod- In this randomized pilot study, 54 postmenopausal women from the outpatient department were supplemented with either micronutrients or placebo for three months. Along with the menopausal symptoms, hemoglobin and lipid profile were assessed.Results- Micronutrients demonstrated moderate to almost complete improvement in symptoms on the 60th and 90th day of the treatment which was better compared to placebo group. The treatment group reported better improvement in night sweats, insomnia and feeling of well-being on the 60th day and almost complete improvement in hot flushes, insomnia, tiredness and feeling of well-being which was significantly better compared to the placebo group (p<0.05) on the 90th day of treatment. No side effects were reported in the micronutrient supplement group.Conclusion- Our findings suggest that the multiple micronutrient supplements are effective in improving postmenopausal symptoms of hot flushes, night sweats, insomnia, depression, tiredness and for improving feeling of well-being. Introduction Menopause, commonly known as the “change of life” for women, is a gradual physiological cessation of menses as a result of decreasing ovarian function. About 75% of women report troublesome symptoms during menopause, but the severity and frequency of symptoms is very inconsistent. The most common symptoms are hot flushes and vaginal atrophy. Other symptoms at the onset include fatigue, irritability, insomnia, depression, night sweats, palpitation and anxiety. The duration of these symptoms is usually one year but last for more than five years in about 25-50% of women.1 Several hormonal products are available and growing. At the same time, use of dietary products to treat menopausal symptoms is also rising. Earlier studies state that women with menopause suffer from osteoporosis due to estrogen deficiency. The bone fragility increases with the additional deficiency of Magnesium. 2Cummings SR concluded that Vitamin D substantially reduced the risk of hip fracture in post menopausal elderly women. 3 The balanced and appropriate multivitamin and mineral supplements containing vitamins (Vitamin A, Riboflavin, Pantothenic acid, Pyridoxine, Folic acid, Vitamin E) and minerals (chromium, copper, magnesium, selenium, silicon, zinc) are essential for the prevention or correction of disorders accompanying menopause like ageing of skin and its accessory structures, decreased bone metabolism, decreased immune function and Evaluation Of The Efficacy And Tolerability Of Micronutrient Supplement... http://www.ispub.com/journal/the-internet-journal-of-gynecology-and-obst... 1 of 6 4/24/2012 10:58 AM