1 The TMEM106B rs1990621 protective variant is also associated with increased neuronal proportion Zeran Li 1,2 , Fabiana G. Farias 1,2 , Umber Dube 1,2 , Jorge L. Del-Aguila 1,2 , Kathie A. Mihindukulasuriya 1,2 , Maria Victoria Fernandez 1,2 , Laura Ibanez 1,2 , John P. Budde 1,2 , Fengxian Wang 1,2 , Allison M. Lake 3 , Yuetiva Deming 4 , James Perez 1,2 , Chengran Yang 1,2 , Joseph Bradley 1,2 , Richard Davenport 1,2 , Kristy Bergmann 1,2 , Bruno A. Benitez 1,2 , Joseph D. Dougherty 1 , Oscar Harari 1,2 , Carlos Cruchaga 1,2,∏ 1.Washington University School of Medicine, St Louis, MO, USA 2. Hope Center for Neurological Disorders, St Louis, MO, USA 3. Vanderbilt University Medical Scientist Training Program, Nashville, TN, USA 4. University of Wisconsin-Madison, Madison, WI, USA. ∏ To whom correspondence should be addressed: Carlos Cruchaga, PhD Professor Department of Psychiatry The Hope Center Program on Protein Aggregation and Neurodegeneration Washington University, School of Medicine 425 S. Euclid Ave. BJC Institute of Heath. Box 8134 St. Louis, MO 63110 Tel: 314-286-0546 Fax: 314-362-2244 Email: ccruchaga@wustl.edu