_____________________________________________________________________________________________________ *Corresponding author: E-mail: chigozie.uchenwoke@unn.edu.ng, ucheman99@gmail.com; Annual Research & Review in Biology 35(5): 91-113, 2020; Article no.ARRB.57971 ISSN: 2347-565X, NLM ID: 101632869 Changes in the Pulmonary Functions of Individuals with Sickle Cell Disease: A Scoping Review Uchenwoke Chigozie Ikenna 1* and Ede Sunday Stephen 1 1 Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria. Authors’ contributions This work was carried out in collaboration between both authors. Author UCI designed the study, wrote the protocol and reviewed the manuscript. Author ESS managed the literature searches and wrote the first draft of the manuscript. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/ARRB/2020/v35i530228 Editor(s): (1) Dr. Viduranga Y. Waisundara, Australian College of Business & Technology, Sri Lanka. Reviewers: (1) Mehrnaz Ahmadi, Ahvaz Jundishapur University of Medical Sciences, Iran. (2) Karishma Singh, PT Deendayal Upadhayay Memorial Health Sciences and Ayush University of Chhattisgarh, India. (3) Prakash Hundekar, Rajasthan University of Health Science, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/57971 Received 10 April 2020 Accepted 16 June 2020 Published 25 June 2020 ABSTRACT Background: Individuals with sickle cell disease (ISCD) are often subject to various changes in crucial health profiles with a consequent need for reduced physical activities, which could be as a result of their declining pulmonary functions. Few studies have systematically attempted to examine the changes in the pulmonary function of ISCD comprehensively. Objective: The purpose of this review is to explore the changes in pulmonary functions of ISCD. Methods: A scoping review comprising 36 studies was conducted to identify and examine the literature related to changes in the pulmonary functions of ISCD, and to compare how they correlate with their health profile. Results: Most common changes cited were demographic factors (26 papers), followed by haematological indices (18 papers) followed by pulmonary complications (16 papers), and anthropometric values (13 papers), with the most common themes overall being age while FEV1, FVC, and FEV1/FVC where the most outcome measures examined. Conclusion: With current advances in medicine, the life expectancy of ISCD is on the increase. Review Article