*Cor Indu 1 Depa Colleg Comm India. Intr Diab well leadi taken chara prog diabe vasc long secre heart diabe vario gluco agen have Since medi the u Herb safe Thi s Antidia rresponding Sanadhya artment of Biotec ge of Arts, Scien merce, Kalyan-42 oduction etes mellitus is as developing c ing causes of de n in to accou acterized by a ressive and is a etic dyslipidaem cular complicatio term damage t etion and failure t and blood ve etes and diab ous oral antidiab osidase inhibitor nts as gemfibroz e number of serio e ancient times icine. Ayurveda use of plants in bal drugs are ea and people hav s work is licen Intern abetic act Indu S g author: chnology, Birla ce and 21304, Mumbai, a major public h countries. [1] It eath and third w unt. [2] Diabe loss of glucose ssociated with o mia which is res ons of diabetes to β- cells of pa e of various orga essels [4, 5]. C etic dyslipoprot betic agents such rs, troglitazone zil and flavastat ous adverse effe s, plants have b and other India n treatment of asily available a ve faith in such r n sed under a C national J http tivity of le Sanadhya 1* , M Ab s The pre Rich. T was ind at 80mg bw was plexus (HDL- c rats fee choleste for antid antidiab showed Adminis degene natural Keywor health problem i is ranked seve when its fatal co tes is a synd e homeostasis. T oxidative stress w sponsible for mi mellitus [3]. Di ancreas which h ans like eyes, k Currently availab teinemia includ h as sulfonylure [6] and anti dys tin [7], but these ects in patients [8 been an exemp an medicinal sy various human at low cost, are remedies [11]. T Creative Com m Journal o p://www.arjo Origin eaves of A induce Meeta Bhot 1 , s tract esent study aims he aqueous ext duced in Sprague g/kg bw. to the r s given orally to of rats were an cholesterol) and ed with aqueo erol, triglyceride diabetic activity betic acitivity was d that alloxan ca stration of aque rated pancreati antidiabetic drug rds: Anthocepha n developed as enth among the mplications are drome, initially The disease is with high risk of cro and macro sease leads to helps in insulin kidneys, nerves, ble therapy for de insulin and a, metformin, - slipoproteinemic e are known to 8 ,9]. plary source of ystems mention n ailments [10]. e comparatively There are many m ons Attribut f Phytom ournals.org/in nal Researc Anthocep ed diabet Jossy Varghe s to examine the tract of leaves w e Dawley adult m rats. Aqueous le control and diab nalysed for seru low density lipo us leaves extr es, HDL and LD were compared s found to be sig aused damage eous leaves ex c islet cells. Th g. lus indicus, antid plants extrac traditio or c phytoc action polysa amino Antho comm has b treatm menor dysen Phytoc terpen reduci indole isodih and amino pheno warm ion 3.0 Licen s medicine 4 ndex.php/ijpm ch Article phalus ind tic rats ese 1 and Nare e antidiabetic po was screened fo male rats by intr eaves extract of betic rats for 21 um glucose lev oprotein (LDL- c ract showed si L as compared d with standard gnificant. Histop in the liver cell xtract caused a hus, Anthoceph diabetic, leaf ext s and plant pro cts) which have b onal system of m linical anti-dia chemical constit n are glycosides accharides, oils, o acids and prote ocephalus indicu monly known as een mentioned ment of fever, rrhagia, blood an ntery and in i constituents in noids, sapogeni ing sugars [15]. e alkaloids; ydrocadambine isocadamine ocadambine A a olic compounds aqueous extra se . 4 (2012) 5 m/index e ndicus A. R esh Chandra 1 otential of leaves or serum glucos ra peritoneal inje Anthocephalus days. Blood sa el, total cholest cholesterol) as gnificant reduct to diabetic rats drug glibenclam athological study s and degenera n improvement halus indicus ca tract, histopatho oducts (active, been mentioned medicine and wh betic activity tuents of plants s, alkaloids, gly vitamins, sapo eins [10]. us A. Rich. belo Kadamba. It is in ancient India anaemia, dia nd skin diseases improvement o the plant c ins, saponins, The leaves of cadambine, 3 [16], two non- g [17], two and aminocada [15, 19]. In tra act of kadamba 511-518 Rich. in a 1 s of Anthocepha se lowering acti ection of alloxan s indicus A. Rich mples taken fro terol, high dens per standard kit tion in blood g . Aqueous leaf e mide at 10mg/kg y of liver and pa ation of pancrea in damaged li an be considere logy natural principle or used in the In hich have shown [12]. Among s credited with ycans, triterpene onins, glycoprote ongs to the fam used as herba an medical liter abetes, uterine s, diarrhoea, col of semen qual consist of indo terpenes, stero Kadamba conta 3 dihydrocada glycosidic alkalo monoterpeno mbine B [18], aditional system a leaves have b alloxan alus indicus A. ivity. Diabetes n monohydrate h. at 400mg/kg m retro orbital sity lipoprotein t method. The glucose, total extract results g bw. and the ancreas of rats atic islet cells. ver cells and ed as a good es and crude ndian n experimental the major hypoglycemic es, mucilages, eins, peptides, mily Rubiaceae al remedy that ratures for the e complaints, itis, stomatitis, lity [13, 14]. ole alkaloids, oids, fats and ains glycosidic ambine and oids; cadamine oid alkaloid; saponins and of remedies, been used to ISSN: 0975-0185