TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection *Yingbiao Ji 1 , *Yun Wei 2,4 , *JoonHyung Park 1 , Li Yin Hung 1,2 , Tanner Young 1 , Karl Herbine 1 , Taylor Oniskey 2 , Christopher Pastore 1 , Wildaliz Nieves 3 , Ma Somsouk 3 , and De’Broski R. Herbert 1,2 1 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19140, USA 2 Division of Experimental Medicine, University of California, San Francisco, San Francisco CA 94110 USA 3 Division of Gastroenterology at ZSFG, University of California, San Francisco, San Francisco CA 94110 USA 4 Department of Inflammation and Oncology, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080. * These authors contributed equally to this work Correspondence: De’Broski R. Herbert Ph.D. University of Pennsylvania School of Veterinary Medicine 3800 Spruce St. Philadelphia, PA 19140 debroski@vet.upenn.edu not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was this version posted November 13, 2018. . https://doi.org/10.1101/469700 doi: bioRxiv preprint