Tejashwini S. Hiremath and Raja Rajeshwari N M: J. Pharm. Sci. Innov. 2020; 9(1) 27 Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com (ISSN : 2277 –4572) Research Article AYURVEDIC MANAGEMENT OF KSHAYAJAKASA – POST COMPLICATION OF MULTIPLE DRUG RESISTANCE TUBERCULOSIS: A CASE STUDY Tejashwini S. Hiremath 1 *, Raja Rajeshwari N M 2 1 PG Scholar, Department of Samhita and Siddhanta, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, India 2 Associate Professor, Department of Samhita and Siddhanta, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, India *Corresponding Author Email: tejashwini818@gmail.com DOI: 10.7897/2277-4572.091164 Received on: 10/11/19 Revised on: 10/12/19 Accepted on: 22/12/19 ABSTRACT The aim of this study is the possible understanding of the case in terms of Ayurveda and a therapeutic protocol with promising result thus reducing the post complication of MDR (Multiple drug resistance) tuberculosis and post AKT treatment. Reporting a case of bronchiectasis, a post MDR tubercular complication of 18-year-old male patient with the main complaints of difficulty in breathing, reduced appetite and loss of weight. Treatment through Ayurvedic approach on OPD and IPD bases is carried out. There is an arrest in further complication, got relief of symptoms, increase in the appetite and weight gain. Understanding the case with Ayurveda aspect as Kshayajakasa (Disease related with the respiratory system) and the line of treatment adopted is Agnideepana (appetizer), Mrudushodhana (mild purification therapy), Shamana (Pacification therapy) and Brumhana (Nourishment) considering the strength (bala) of the person. Treating the post complication of tuberculosis through Ayurvedic approach is helpful in increasing the lifespan of the person by reducing its complication. Keywords: Bronchiectasis, MDR TB (multiple drug resistance tuberculosis), Kshayajakasa INTRODUCTION Globally tuberculosis (TB) is one of the leading causes of death due to an infectious disease second only to HIV/AIDS and one among top 10 causes of death worldwide. Estimates suggest that approximately one-third of the world's population is infected with Mycobacterium tuberculosis, the microbe that causes TB, and ∼10% of infected individuals will develop active TB at some point in their lives. As per 2015 survey it is suspected that 19 - 40 age group was affected TB with MDR (Multiple Drug Resistance). 1 As per WHO report of 2016, Ending of TB epidemic by 2030 is foremost health target goal. So to combat such cases, WHO has addressed 6 core functions, important one among is the evidence based strategies and standards for prevention, care and control through integrative medicine. 2 In the Ayurveda field research works such as add on therapy in TB have been undertaken and got successful results. 3 The Present case being diagnosed in 2015 with MDR-TB at the age of 18, undergone AKT for about 1year 5months and this case approached with the post complication of Koch’s i.e. Bronchiectasis. With the symptoms of difficulty in breathing, cough with copious foul yellowish sputum in morning of about 50 – 100 ml, Loss of weight (there is more weight loss after the completion of AKT) and AFB report was negative. The case was successfully treated through ayurvedic approach. Case report Male Patient aged 21 years, Student, admitted on 28/12/17 with OPD No 119761 and IPD No. 27410; Discharged on 1/1/18. Approached with the main complaints of Difficulty in breathing while climbing the stairs, walking for little distance (about 10 steps) since 1 ½ years. Cough with copious foul expectorant early morning (yellowish green) for about 50-100 ml. Loss of weight – since 3 years and associated with general weakness. H/O of Present illness K/C/O Koch’s, after completion of AKT he felt reduction in symptoms such as blood tinged Sputum, cough and fever. After some days he developed difficulty in breathing on climbing the stairs, walking for little distance (about ten steps) and exertion on doing little work. Cough with yellowish green expectorant early in morning and on exposure to cold and dust it was aggravated. Gradually reduction of weight, loss of appetite, chest pain, weakness and repeated fever was also associated with the main complaints. After six months of treatment, appetite was improved but no changes observed in other complaints. Past history The patient was migrated to the hostel for education three years back. The appearances of the symptoms are simultaneous with co- hosteller. After six months of asymptomatic phase, developed disturbed sleep, occasional cough with blood stained sputum, for which no medication was consumed. There after patient visited consultant at residential area, when symptoms got aggravated and there diagnosed as TB based on laboratory investigations. Because of severity of the disease (MDR) AKT treatment was advised for one year five months. No family members had suffered from Koch’s or any other contagious diseases.