QUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology REVI EW ARTI CLE Published Online: 24 May 2021 Page 41 of 55 * Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia * Corresponding Author: deny@iium.edu.my Received: 11 September 2020 Accepted: 22 April 2021 Published: 24 May 2021 © Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 2021. Accreditation Number:148/M/KPT/2020. ISSN: 2089-5690, e-ISSN: 2406-9272. doi: 10.15578/squalen.514 OPEN ACCESS SQUALEN BULLETIN I ntroduction Seaweeds, also known as macroalgae, are composed of large, diverse macroscopic, eukaryotic, photosynthetic and non-vascular marine organisms. Garcia-Vaquero, Lopez-Alonso, and Hayes (2017) had listed 10,000 different species of seaweeds, which occupy the littoral zone. The structure of seaweeds is varied, as some are filamentous with a few millimeters in height, while others have huge fronds up to 60- meter long. Also, the seaweeds’ chemical structure and bioactive compounds are varied based on their habitats, which are either in the harsh marine or terrestrial environment (Garcia-Vaquero et al., 2017). Seaweeds are classified into three higher taxa, namely Chlorophyta (green seaweed), Phaeophyta (brown seaweed) and Rhodophyta (red seaweed), based on their pigmentation. Bioactive Compounds, Cosmeceutical And Nutraceutical Applications of Green Seaweed Species ( Chlorophyta ) Fatin Shazwani Ruslan, Deny Susanti *, Normawaty Mohammad Noor, Nurul Iman Aminudin, and Muhammad Taher Abstract Seaweeds are valuable marine plants that have garnered much attention from the public due to their high bioactive, nutrients and minerals content. Seaweeds have been used in multiple applications, including in cosmeceutical, nutraceutical and pharmaceutical industries. Nevertheless, this review will focus on the bioactive compounds of Chlorophyta and their potential application in nutraceutical and cosmeceutical industries. Chlorophyta are believed to possess a significant amount of nutrients and minerals, sufficient to meet the daily requirements of nutrients and minerals in the human body. Considering the nutritional aspect, deficiency in nutrients may lead to severe ailments, including heart disease, neurological disorder and cancer. The main compounds studied in this review are polysaccharides, proteins, amino acids, lipids, fatty acids, pigments, minerals, vitamins and secondary metabolites. Among all, polysaccharides are the most exploited compounds and used in many advanced applications in the nutraceutical and cosmeceutical industries. This review also offers insights into the beneficial biological properties of Chlorophyta, highlighting their potential in cosmeceutical and nutraceutical applications. Further research is required to highlight the Chlorophyta sp. aquaculture, its extraction method, and the most targeted bioactive compounds from the species. Therefore, the challenge is to increase public awareness of the promising application of this species in the nutraceutical and cosmeceutical industries. Keywords: chlorophyta, cosmeceutical, nutraceutical Seaweeds have been consumed as a type of sea vegetable in most countries such as Japan, China and Korea. They have become a source of hydrocolloids (alginate, carrageenan, and agar), thickening and gelling agents and had been utilized in industrial and foods across Western countries (Pereira, 2018). At present, there is a high demand for seaweeds as many quarters have begun consuming healthy and ‘natural foodstuffs’, mainly because seaweeds are rich in minerals, vitamins, and proteins. Additionally, the French consumed several types of macroalgae and microalgae in their meals as vegetables or condiments. They have also been widely known and used as a source of fertilizer and thickening agents. Meanwhile, in Japan, seaweeds make up to 10-25 % of food intake as they used seaweeds as sushi wrappings, seasonings, condiments and vegetables (Miyamoto, Yabuta, Kwak, Enomoto, & Watanabe, 2009). Seaweeds species have been in high demand in