Mol2Net, 2015, 1(Section A, B, C, etc.), pages 1- x, type of paper, doi: xxx-xxxx 1 http://sciforum.net/conference/mol2net-1 Mol2Net “Statistically optimized binary ethosomal gel of Carvedilol: allevialates hypertenstion in male Wistar albino rats” Thota Sunil Kumar 2 and Ananda Kumar Chettupalli *,1 2. Department of Pharmaceutics, University college of Pharmaceutical Sciences (UCPSc), Kakatiya university, Vidyaranyapuri, Hanamakonda, Warangal, Telangana 506009, India. sunithasunilthota@gmail.com, +91- 9849237235, +91- 9502020950. * Department of Pharmaceutics, School of Pharmacy, Anurag Group of Institution, Venkatapur, Medchal, Hyderabad-500088, Telangana, India.- anandpharmacy@cvsr.ac.in +91- 9849922424, +91- 6303132567. Received: / Accepted: / Published: Abstract: The current study entails novel advanced formulation approach binary ethosomal gel containing Carvedilol and evaluating the optimized formulation for hypertension. Carvedilol is an antihypertensive agent, which undergoes hepatic metabolism and shows poor bioavailability of just 20 %. Carvedilol binary ethosomal suspension was optimized using central composite design (CCD). In which quantities of lipid (A), ethanol (b), and propylene glycol (C) were selected independent variables; vesicle size (Y1), entrapment efficiency (Y2) and cumulative %drug release (Y3) were selected as dependent variables. The composition of optimum formulation was found as 2 % of lipid (Soya lecithin), 20 % of ethanol, and 10 % of propylene glycol. The optimized binary ethosomal suspension (OBE) had shown a vesicle size, poly dispersable index, ztapotential, cumulative % drug release, and %entrapment efficiency of 130±1.72nm, 0.230±0.03, -31±1.8MV, 97.89±3.7 %, and 99±2.96 % respectively. This was further evaluated and compared with liposomes. Scanning electron microscopy studies revealed that OBE was in spherical shape. The OBE was converted to hydrogel and evaluated for rheological properties. The OBE- Gel (OBE-G) attained mean transdermal flux of 0.0644±0.002 mg/cm 2 .h through rat skin. This formulation showed a substantial and constant decrease SciForum