Physiological Communication Biosci. Biotech. Res. Comm. 9(3): 341-348 (2016) Cognitive type susceptibility in ICR mice model of chronic cerebral hypoperfusion. Sirilak Somredngan 1 and Wachiryah Thong-asa 1 * 1 Physiology Division, Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand. ABSTRACT Animal model of chronic cerebral hypoperfusion (CCH) was found to be benefcial as pathophysiological provided relevance to vascular dementia (VD) and subcortical ischemic vascular dementia (SIVD). There were many evidence kinds of CCH animal model and all were useful. The present study investigated the pathophysiology of mild CCH in ICR mice during 2 to 8 weeks of permanent right common carotid artery occlusion Sensorimotor, cognitive abilities and anxiety-like behavior were assessed in Morris water maze (MWM) and elevated plus maze (EPM), respectively. Frontal cortex, striatum and hippocampus infarctions were evaluated using 2% 2,3,5-triphenyltetrazolium chloride (TTC) at 2, 4 and 8 weeks of permanent right common carotid arteryocclusion. Sensorimotor, spatial learning and memory in the acquisition paradigm of the MWM and anxiety-like behavior assessed in the EPM were not affected during the experimental period of 2, 4 and 8 weeks of arterial occlusion.Signifcant defcit of learning fexibility and memory of reverse platform location in the reversal paradigm were found, though reversible of learning fexibility defcit presented at 8 weeks. Signifcant infarction early appeared in striatum since 4 weeks while the frontal cortex and hippocampus stated at 8 weeks. The present study suggested that mild CCH induced by permanent right com- mon carotid artery occlusion in ICR mice induced reversible learning fexibility defcit but not memory of the reverse platform location in the MWM. KEY WORDS: CHRONIC CEREBRAL HYPOPERFUSION, ELEVATED PLUS MAZE,LEARNING FLEXIBILITY, SPATIAL LEARNING AND MEMORY. 341 ARTICLE INFORMATION: *Corresponding Author: fsciwyth@ku.ac.th Received 20 th Aug, 2016 Accepted after revision 7 th Sep, 2016 BBRC Print ISSN: 0974-6455 Online ISSN: 2321-4007 Thomson Reuters ISI ESC and Crossref Indexed Journal NAAS Journal Score 2015: 3.48 Cosmos IF : 4.006 © A Society of Science and Nature Publication, 2016. All rights reserved. Online Contents Available at: http//www.bbrc.in/ INTRODUCTION Animal model of chronic cerebral hypoperfusion (CCH) can be induced by permanent ligation of major cerebral arterial supplies. Severity of pathological appearances depended on the number of vessel occlusion and persis- tent of cerebral reduction. CCH study in animal model is associated with cerebral blood fow (CBF) reduction, metabolic insuffcient, oxidative stress, neuroinfam- mation, neurotransmitter system dysfunction, mental confusion, cognitive decline, white matter and neu- ronal degeneration. These pathological relevancies of