Research Article Laparoscopic versus Open Complete Mesocolic Excision for Right Colon Cancer Ali Zedan , 1 Essam Elshiekh, 2 MohamedIOmar , 1 Mohamad Raafat, 3 Salah M. Khallaf, 4 Haisam Atta, 5 and Marwa T. Hussien 6 1 Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Asyut, Egypt 2 Department of Surgical Oncology, Tanta Cancer Center, Tanta, Egypt 3 Department of General Surgery, Faculty of Medicine, Assiut University, Asyut, Egypt 4 Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Asyut, Egypt 5 Department of Diagnostic Radiology, South Egypt Cancer Institute, Assiut University, Asyut, Egypt 6 Department of Oncologic Pathology, South Egypt Cancer Institute, Assiut University, Asyut, Egypt Correspondence should be addressed to Ali Zedan; alizedan73@yahoo.com Received 27 July 2020; Revised 17 January 2021; Accepted 22 January 2021; Published 2 February 2021 Academic Editor: C. H. Yip Copyright © 2021 Ali Zedan et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background and Objectives. e use of complete mesocolic excision (CME) technique seems to be gaining popularity in the management of cancer colon. We aim to compare the laparoscopic approach for CME with the open approach in right colon cancer treatment with regard to the feasibility, safety, and perioperative and oncologic outcomes. Patients and Methods.A prospective study which included all patients that underwent radical right hemicolectomy for pathologic confirmed stage II or stage III tumor with CME at South Egypt Cancer Institute, Assiut University, from January 2012 to December 2019. Patients were grouped according to the surgical approach into the laparoscopic colectomy (LCME) group (n � 48) or open colectomy (OCME) group (n � 48). Results. e mean operative time was significantly longer in the LCME group than that in the OCME group with less mean intraoperative blood loss. Conversion was required in 4 patients (8.3%) in the LCME group. e use of laparoscopy increased the number of harvested lymph nodes compared to the open approach (39.81 ± 16.74 vs. 32.65 ± 12.28, respectively, P � 0.010). e laparoscopic approach was associated with a shorter time interval to first flatus as well as shorter time interval to liquid and normal diet after surgery. e postoperative hospital stay was significantly shorter in the LCME group. e com- plication rate was slightly lower in the LCME (14.7%) than in the OCME group (27.2%) (P � 0.252). e 3-year OS in the LCME group was similar to that in OCME (78.2% vs. 63.2%, respectively, P value � 0.423). e three-year DFS in the laparoscopic group was higher (74.5%) than the open group (60.0%), but did not reach statistical significance (P value � 0.266). Conclusions. In conclusion, laparoscopic CME right hemicolectomy is a technically feasible and safe procedure if surgeon expertise is present. LCME has long-term oncologic outcomes (recurrence and survival) comparable to open surgery for management of patients with stage II or III colon cancer. 1. Introduction In 2009, Dr. Hohenberger first proposed the concept of complete mesocolic excision (CME) for colon cancer sur- gery [1] according to the concept of total mesorectal excision (TME) for rectal cancer. e technique of CME relies on three key components: (I) sharp dissection in the embryologic plane between the parietal fascia and visceral (mesenteric) fascia to remove mesentery together with its lymphatic drainage as an intact envelope [2]; the principle behind this technique is to avoid any inadvertent exfoliation of the tumor cells from mesentery into the peritoneal cavity; (II) proximal ligation of feeding vessels at their origin to remove apical lymph nodes; and (III) resection of a sufficient length of bowel to remove potentially involved lymph nodes in a longitudinal direction [3]. After postulation of CME technique, CME with central vascular ligation (CVL) has been applied by many European Hindawi International Journal of Surgical Oncology Volume 2021, Article ID 8859879, 8 pages https://doi.org/10.1155/2021/8859879