Dhapake et al Journal of Drug Delivery & Therapeutics. 2019; 9(1-s):501-504 ISSN: 2250-1177 [501] CODEN (USA): JDDTAO Available online on 15.02.2019 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Review Article A review on experimental pharmacology Devika Balagopalan 1 *, Gazala Hussain 2 , M M Nidhin 1 , Sruthi Nambiar 1 1 PG Scholar, Department of Rasashastra and Bhaishajya kalpana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka 2 Associate Professor, Department of Rasashastra and Bhaishajya kalpana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka ABSTRACT In this era where the pharmaceutical companies and products are hiking in its need and production it is inevitable to document the safety and toxicity along with the indications of the same. This is where the experimental study has a vital role to play. Experimental pharmacology is the science where the drug interaction with different receptors and target sites in living organism are explained. This article reviews about the different aspects of experimental pharmacology and its uses. Keywords: Experimental pharmacology, products, dosage Article Info: Received 05 Dec 2018; Review Completed 20 Jan 2019; Accepted 23 Jan 2019; Available online 15 Feb 2019 Cite this article as: Balagopalan D, Hussain G, Nidhin MM, Nambiar S, A review on experimental pharmacology , Journal of Drug Delivery and Therapeutics. 2019; 9(1-s):501-504 http://dx.doi.org/10.22270/jddt.v9i1-s.2242 *Address for Correspondence: Devika Balagopalan, PG Scholar, Department of Rasashastra and Bhaishajya kalpana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka INTRODUCTION Pharmacology a unique branch of biology, deals with the study of drugs, where a drug can be defined as a man-made natural or endogenous molecule which exerts a biochemical or physiological effect on cells, tissues or organs. To be more specific it is the study of interactions that occurs between a living organism and chemicals that affect normal or abnormal biochemical functions. It is also expounded as the discovery of new drug or to study the action of an existing one. Experimental pharmacology implicates the study of pharmacology through bioassay or to test the effect of various pharmacological agents on different animal species. History of Pharmacology 2500 years ago during 17 th century in Greek experiments were done on Willow leaves. 17 th to 18 th cent Salicylic acid was tested on willow leaves. 1899 - Bayer marketed Acetyl salicylic acid (Aspirin). 1970- Mechanism of inhibition of prostaglandin synthesis via Cyclo oxygenase cox enzyme. Rudolf Buchheim is known as the founder of experimental pharmacology. Oswald Schmiedeberg the founder of modern pharmacology 1 . Basics of Experimental Pharmacology It consists of three elements: subjects, treatment and efficacy. Treatment is again divided as primary, secondary and tertiary. Three Principles of Study Design Randomization- to avoid subjective bias in research Replication- number of times the experiment repeated under same conditions and number of samples used in experiment Control- self-control design, block control design or case design Design of Sample Size Empirical method for determination of sample size:- Sl. No. Animals Quantitative Qualitative 1. Mouse, rat, frogs, fish >/=10 >/=30 2. Guinea pig, rabbit >/=6 >/=30 3. Cat, monkey, sheep, dog 5-10