biology Article Harvest Season Significantly Influences the Fatty Acid Composition of Bee Pollen Saad N. Al-Kahtani 1 , El-Kazafy A. Taha 2, * , Soha A. Farag 3 , Reda A. Taha 4 , Ekram A. Abdou 5 and Hatem M Mahfouz 6   Citation: Al-Kahtani, S.N.; Taha, E.-K.A.; Farag, S.A.; Taha, R.A.; Abdou, E.A.; Mahfouz, H.M Harvest Season Significantly Influences the Fatty Acid Composition of Bee Pollen. Biology 2021, 10, 495. https:// doi.org/10.3390/biology10060495 Academic Editor: Alessandra Durazzo Received: 2 May 2021 Accepted: 28 May 2021 Published: 2 June 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil- iations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 Arid Land Agriculture Department, College of Agricultural Sciences & Foods, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia; salkahtani@kfu.edu.sa 2 Department of Economic Entomology, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516, Egypt 3 Department of Animal and Poultry Production, Faculty of Agriculture, University of Tanta, Tanta 31527, Egypt; soha.farag@agr.tanta.edu.eg 4 Agricultural Research Center, Bee Research Department, Plant Protection Research Institute, Dokki, Giza, Egypt; reda0164184487@yahoo.com 5 Agricultural Research Center, Plant Protection Research Institute, Dokki, Giza, Egypt; ekram01225967276@gmail.com 6 Department of Plant Production, Faculty of Environmental Agricultural Sciences, Arish University, Arish 45511, Egypt; hatemmahfouz@yahoo.com * Correspondence: elkazafi.taha@agr.kfs.edu.eg Simple Summary: Harvesting pollen loads collected from a specific botanical origin is a complicated process that takes time and effort. Therefore, we aimed to determine the optimal season for harvesting pollen loads rich in essential fatty acids (EFAs) and unsaturated fatty acids (UFAs) from the Al- Ahsa Oasis in eastern Saudi Arabia. Pollen loads were collected throughout one year, and the tested samples were selected during the top collecting period in each season. Lipids and fatty acid composition were determined. The highest values of lipids concentration, linolenic acid (C 18:3 ), stearic acid (C 18:0 ), linoleic acid (C 18:2 ), arachidic acid (C 20:0 ) concentrations, and EFAs were obtained from bee pollen harvested during autumn. The maximum values (%) of oleic acid (C 18:1 ), palmitic acid (C 16:0 ), UFAs, and the UFA/saturated fatty acid (SFA) ratio were found in bee pollen harvested during summer. Bee pollen harvested during spring ranked second in its oleic, palmitic, linolenic, stearic, arachidic, behenic, and lignoceric acid concentrations and for EFAs, UFAs, and the UFA/SFA ratio. It was concluded that the FA composition of bee pollen varied among the harvest seasons. We recommend harvesting pollen loads during spring and summer to feed honeybee colonies during periods of scarcity and for use as a healthy, nutritious food for humans. Abstract: Seasonal variations in the fatty acid (FA) compositions of pollen loads collected from the Al-Ahsa Oasis in eastern Saudi Arabia throughout one year were determined to identify the optimal season for harvesting bee pollen rich in essential fatty acids (EFAs) and unsaturated fatty acids (UFAs). The highest values (%) of lipids, linolenic acid (C 18:3 ), stearic acid (C 18:0 ), linoleic acid (C 18:2 ), arachidic acid (C 20:0 ), the sum of the C18:0, C18:1, C18:2, and C18:3 concentrations, and EFAs were obtained from bee pollen harvested during autumn. The maximum values (%) of oleic acid (C 18:1 ), palmitic acid (C 16:0 ), UFAs, and the UFA/saturated fatty acid (SFA) ratio were found in bee pollen harvested during summer. The highest concentrations (%) of behenic acid (C 22:0 ), lignoceric acid (C 24:0 ), and SFAs were found in bee pollen harvested during winter. Bee pollen harvested during spring ranked second in its oleic, palmitic, linolenic, stearic, arachidic, behenic, and lignoceric acid concentrations and for EFAs, UFAs, and the UFA/SFA ratio. The lowest SFA concentration was found in bee pollen harvested during summer. Oleic, palmitic, and linolenic acids were the most predominant FAs found in bee pollen. It was concluded that the FA composition of bee pollen varied among the harvest seasons due to the influence of the dominant botanical origins. We recommend harvesting pollen loads during spring and summer to feed honeybee colonies during periods of scarcity and for use as a healthy, nutritious food for humans. Biology 2021, 10, 495. https://doi.org/10.3390/biology10060495 https://www.mdpi.com/journal/biology