http://www.revistadechimie.ro REV.CHIM.(Bucharest)♦70♦ No. 4 ♦2019 1434 Diabetic Retinopathy in Relation with eGDR Value in Patients with Type 1 Diabetes Mellitus DIANA CLENCIU 1# , TIBERIU STEFANITA TENEA COJAN 2 *, ANDA LORENA DIJMARESCU 3# , CRISTINA GABRIELA ENE 4 , DRAGOS VIRGIL DAVITOIU 5# , VLAD DUMITRU BALEANU 6# , COSMIN ALEXANDRU CIORA 7 , BOGDAN SOCEA 8 , DANIEL-IULIAN VOICULESCU 9# , RAMONA-MIHAELA NEDELCUTA 10# , VERONICA CALBOREAN 11# , VICTOR GHEORMAN 12# , IONELA MIHAELA VLADU 13 1 University of Medicine and Pharmacy of Craiova, Department of Metabolism and Nutrition Diseases, Filantropia Clinical Hospital of Craiova, 1 Filantropiei Str., 200143, Craiova, Romania 2 University of Medicine and Pharmacy of Craiova, Department of Surgery, CFR Hospital of Craiova, Stirbei-Voda Str., 200374,Craiova, Romania 3 University of Medicine and Pharmacy of Craiova, Obstretics-Gynecology Department, Filantropia Clinical Hospital of Craiova , 1 Filantropiei Str., 200143, Craiova, Romania 4 University of Medicine and Pharmacy of Craiova, Pharmacology Department, County Hospital of Craiova, 2-4 Petru Rares Str., 200349, Craiova, Romania 5 University of Medicine and Pharmacy of Bucharest, Surgery Department, Clinical Emergency Hospital Sf. Pantelimon Bucharest, 340-343 Pantelimon Road, 021659, Bucharest, Romania 6 University of Medicine and Pharmacy of Craiova, Surgery Department, Clinical Emergency Hospital Sf. Pantelimon Bucharest, 340-343 Pantelimon Road, 021659, Bucharest, Romania 7 Carol Davila University of Medicine and Pharmacy, Discipline of Gastroenterology and Hepatology, 8 Eroii Revolutiei Blvd., 050474, Bucharest, Romania 8 General Surgery Clinic, Emergency Clinical Hospital Sfantul Pantelimon, 340-342 Pantelimon Road, 021659, Bucharest, Romania 9 University of Medicine and Pharmacy Carol Da vila Bucharest, Department ofSurgery Universitary Emergency Hospital Bucharest, 169 Splaiul Indepenei, 050098, Bucharest, Romania 10 University of Medicine and Pharmacy of Craiova, Pediatrics Department, 2 Petru Rares Str., 200349, Craiova, Romania 11 University of Medicine and Pharmacy of Craiova, Cardiology Department, 2 Petru Rares Str., 200349, Craiova, Romania 12 University of Medicine and Pharmacy of Craiova, Psychiatry Department, Neuropsychiatry Hospital of Craiova, 24 Aleea Potelu Str., 200473, Craiova, Romania 13 University of Medicine and Pharmacy of Craiova, Department of Metabolism and Nutrition Diseases, Filantropia Clinical Hospital of Craiova, 1 Filantropiei Str., 200143, Craiova, Romania Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Type 1 diabetes is occurred most frequently in childhood and adolescence, although in recent years due to the increase in the prevalence of obesity in this category of population has been registered a growing number of cases of type 2 diabetes among children and adolescents (1, 2). Keywords: Type 1 diabetes mellitus, diabetic retinopathy, insulin resistance Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Type 1 diabetes is occurred most frequently in childhood and adolescence, although in recent years due to the increase in the prevalence of obesity in this category of population has been registered a growing number of cases of type 2 diabetes among children and adolescents [1, 2]. As a result of the vascular complications, diabetes is the main cause of blindness, being responsible for up to 40% of the cases of kidney failure and is a determinant key of staff morbidity and mortality by cardiovascular cause [3-5]. Insulin resistance has been linked to the pathophysiology of type 2 diabetes mellitus (T2DM) and it has been proved to have an important role in the increase of the risk of cardiovascular complications [6-12]. It has been recently shown that insulin resistance plays an important role in the natural history of type 1 diabetes, although it is generally known that it is mainly due to immune destruction of the β-pancreatic cells [13-15]. Ginsberg has studied the association of insulin resistance with T1DM [16-17]. Subsequent studies [18-21] showed a significant decrease in glucose disposal mediated by insulin among patients with T1DM suggesting the presence of insulin resistance. After a decade this combination has aroused the interest of many research studies [22-30] to investigate the possible mechanisms of insulin resistance in T1DM. Experimental part The aim of the study The study aims are to determine the prevalence of diabetic retinopathy in Type 1 DM and to correlate it with the presence of risk factors (lifestyle, disease evolution status, onset of disease, metabolic control). Also, we tried to assess the degree of insulin resistance and its correlation with the occurrence of diabetic retinopathy. Material and methods The observational cross sectional survey was conducted over a three-year period 2010-2013. The timing of exploration of the patients under study consisted of a complete initial assessment of inclusion in the study group. *email: doctortts@yahoo.com; Phone: 0746095969 # The authors contributed equally to the manuscript and share first authorship.