SUPPORTING INFORMATION SULFUR-ASSISTED DOMINO ACCESS TO BICYCLIC DIHYDROFURANS: CASE STUDY AND EARLY SYNTHETIC APPLICATIONS Concetta Paolella, Daniele D’Alonzo,* Giovanni Palumbo and Annalisa Guaragna* Dipartimento di Scienze Chimiche, Università di Napoli Federico II via Cintia, 21 I-80126 Napoli, Italy dandalonzo@unina.it; guaragna@unina.it EXPERIMENTAL SECTION 1 COPIES OF 1 H AND 13 C NMR SPECTRA methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate (6) 7 2-((t-butyl(diphenyl)silyl)oxy)-1-(3-(((4-methoxybenzyl)oxy)methyl)- 5,6-dihydro-1,4-dithiin-2-yl)-1-ethanone (7) 8 2-((t-butyl(diphenyl)silyl)oxy)-1-(3-(((4-methoxybenzyl)oxy)methyl)- 5,6-dihydro-1,4-dithiin-2-yl)-1-ethanol (8) 9 5-((t-butyl(diphenyl)silyl)oxy)-7-methoxy- 2,3,5,7-tetrahydro-[1,4]dithiino[2,3-c]furan (9) 10 2-(((t-butyl(diphenyl)silyl)oxy)methyl)furan (10) 11 5-((t-butyl(diphenyl)silyl)oxy)-5,7-dimethoxy-2,3,5,7- tetrahydro[1,4]dithiino[2,3-c]furan (11) 12 5-[(t-butyldiphenyloxy)methyl]-5,7-bis-(trideuteromethoxy)- 2,3,5,7-tetrahydro[1,4]dithino[2,3-c]furan (26) 13 5-[(t-butyldiphenyloxy)methyl]-5,7-bis-(2,2,2-trifluoroethoxy)- 2,3,5,7-tetrahydro[1,4]dithino[2,3-c]furan (27a) 14 5-[(t-butyldiphenyloxy)methyl]-5,7-bis-(2-propynyloxy)- 2,3,5,7-tetrahydro[1,4]dithino[2,3-c]furan (27b) 15 -[(t-butyldiphenyloxy)methyl]-5,7-diisopropoxy- 2,3,5,7-tetrahydro[1,4]dithino[2,3-c]furan (27c) 16 2-(((t-butyl(diphenyl)silyl)oxy)methyl)-2,5-dimethoxy-2,5-dihydrofuran (18) 17 N1-(1-(7-((t-butyl(diphenyl)silyl)oxy)methyl)- 7-methoxy-2,3,5,7-tetrahydro[1,4]dithiino[2,3-c]furan-5-yl- 2-oxo-1,2-dihydro-4-pyrimidinyl)acetamide (28 and 28) 18-19 N1-(1-(5-(((t-butyl(diphenyl)silyl)oxy)methyl)-5-methoxy-2,5-dihydro- 2-furanyl)-2-oxo-1,2-dihydro-4-pyrimidinyl)acetamide (30 and 30) 20-21 4-amino-1-(5-(hydroxymethyl)-5-methoxy-2,5-dihydro-2-furanyl)- 1,2-dihydro-2-pyrimidinone (31 and 31) 22-23 Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is © The Royal Society of Chemistry 2013