Sanchit et al Journal of Drug Delivery & Therapeutics. 2015; 5(6):14-17 14 © 2011-15, JDDT. All Rights Reserved ISSN: 2250-1177 CODEN (USA): JDDTAO Available online on 15.11.2015 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open access to Pharmaceutical and Medical research © 2015, publisher and licensee JDDT, This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited REVIEW ARTICLE BIOLOGICALLY ACTIVE PYRIMIDINE HYDRAZONES Srivastav Sanchit*, Luhach Kanishk, Shukla Chhama, Yadav Rajender Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308 *Corresponding Author’s Email: srivastavsanchit@gmail.com, Mobile No: +918800688147 Received 23 Sep 2015; Review Completed 14 Oct 2015; Accepted 15 2015, Available online 15 Nov 2015 1. INTRODUCTION Medicinal chemistry is the branch of science that deals mainly with the synthetic organic chemistry and pharmacology of the drugs with special references to structure including design, modifications and analysis of drugs or chemical synthesis of lead compounds to make them suitable for the mankind or animals with least toxicity and optimum response 1 . Heterocyclic chemistry is a very important branch of organic chemistry and most of the organic synthetic or semi synthetic compounds are heterocyclic in structural properties. Its structure can be described with carbon atoms in ring forming carbocyclic compound 2 . The most common heteroatoms are Nitrogen, oxygen and sulfur. But heterocyclic rings containing other hetero atoms are having in broad variety. Heterocyclic compounds can be classified as aliphatic and aromatic. The aliphatic heterocyclics are the cyclic similarities of amines, ethers, thio ethers, amides, etc. Heterocyclic compounds are having importance in various medicinal formulations and are present in a large variety of drugs, most vitamins, natural products etc. In addition to this biologically active compounds, including antitumor, antibiotic, anti-inflammatory, antidepressant, antimalarial, anti-HIV, antimicrobial, antibacterial, antifungal, antiviral, antidiabetic, herbicidal, fungicidal, anticonvulsant, and insecticidal agents 3 . 1.1 Pyrimidine Heterocyclic aromatic organic compound like benzene or pyridine, having two nitrogen atoms at positions 1 and 3 of the six-membered ring; they have isomers in the forms of diazine 4 Figure 1 ABSTRACT Pyrimidine constitutes an important class of heterocycles in drug discovery & is very well known for their anticancer, antimicrobial, antioxidant & antiviral activities. Hydrazones is a class of organic compounds with the structure R 1 R 2 C=NNH 2. They are formed usually by the action of hydrazine on ketones or aldehydes & have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidine hydrazones can be prepared by the reaction of “4-(4-Chloro-phenyl)- 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide” with various terpenes such as citral, camphor, furfuraldehyde & menthone to make Schiff bases individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives. The present studies revealed that Pyrimidine hydrazone derivatives could be used to synthesize the compounds having potent biological activities such as anticancer, antimicrobial, antioxidant, CNS depressant, analgesic & antiviral activities. All the prepared derivatives were under investigation for their antimicrobial activity and likely to possess the same & desired action. Keyword: Pyrimidine Hydrazones, Biological active Pyrimidine, Schiff Bases etc.