Summary: Chikungunya is one of the most rapidly spreading Aedes mosquito-borne viral infectious diseases. Recently in Bangladesh it has emerged as an important public health issue. Chikungunya virus (CHIKV) mostly spread by Aedes aegypti and Aedes albopictus, an anthropophilic mosquito species widely distributed in Asia, Europe, Africa and America. Our objective was to determine the clinical, biochemical and radiological features of patients at the acute phase of CHIKV infection. The purpose of study was to evaluate the literature and summarize the current state of CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe diseases, complications and treatment. We present 253 confirmed cases of chikungunya having different clinical presentations occurring among adult patients from different background including foreigner in Dhaka city, admitted in a tertiary level hospital situated in Gulshan from march17 to November 2017 . All patients had fever and joint pain. Other common features were rash, diarrhoea, vomiting, confusion, and altered liver biochemistry. Adult patients with multiple co-morbidities admitted in hospital with male preponderance of 59 % and rest were female 41%. Most common complication was post CHIKV arthritis (79%) and rest of the less common complications were post viral asthenia (34%), myocarditis (27%), pneumonitis (30%). Dengue was excluded in all patients. Paracetamol remained the mainstay of treatment during febrile periods, but around 62% of the patients had prolonged joint symptoms requiring non-steroidal anti- inflammatory drugs, colchicines, steroid. Among joint involvement, ankle joints were commonly involved joint presented with post viral arthritis. Since there is no specific treatment of chikungunya, prevention through vector control and public health education is the key. Key words: Chikungunya fever, Viral infectious disease. (J Bangladesh Coll Phys Surg 2019; 37: 124-129) DOI: https://doi.org/10.3329/jbcps.v37i3.41734 a. Dr. Safia Binte Rabbani, Specialist in Medicine, United Hospital Limited. b. Dr. Pradip Ranjan Saha, Consultant, Department of Internal Medicine, United Hospital Ltd. c. Dr. Md. Iqbal Hossain, Consultant, Department of Internal Medicine, United Hospital Ltd. d. Dr. Afsana Begum, Consultant, Department of Internal Medicine, United Hospital Ltd. e. Dr. Md. Jahangir Talukder, Consultant, Department of Internal Medicine, United Hospital Ltd. Address of Correspondence: Dr. Safia Binte Rabbani, Specialist, Medicine Department, United Hospital Limited. Phone: 01715003919, Email: safia_rabbani@yahoo.com Received: 10 June, 2018 Accepted: 16 March, 2019 A Clinical Study on Chikungunya Fever in a Multidisciplinary Hospital of Dhaka City SB RABBANI a , PR SAHA b , MI HOSSAIN c , A BEGUM d , MJ TALUKDER e Journal of Bangladesh College of Physicians and Surgeons Vol. 37, No. 3, July 2019 Introduction: Chikungunya is caused by a vector-borne virus of genous Alphavirus and family Togavirus. Aedes aegypti and Aedes albopictus are the usual vectors, which are also responsible for transmission of dengue, hence there is concurrence or co-incidences of dengue and chikungunya in endemic regions 1 . In Bangladesh, over the past two decades, dengue had been recognized as endemic disease with high incidence during the rainy seasons. Last year’s outbreak of chikungunya also parallels the same seasonal and environmental characteristics of dengue in Dhaka, Bangladesh. Aedes albopictus 2 was the main vector in 2011 outbreak in Dhaka. Scientists forecasted chikungunya as an emerging viral infection in Bangladesh in 2014 as well 3 . Methods : A retrospective observational study enrolled 253 consecutive patients older than 20 years with fever, arthralgia, rash admitted at the tertiary level hospital situated in gulshan, Dhaka city from March 2017 to November 2017. Biological confirmation of CHIKV infection was obtained for all patients, either by detection of CHIK virus RNA in the blood during acute stage by RT-PCR or the presence of anti-CHIK virus specific immunoglobulin M by ELISA depending on delayed presentation. And dengue was excluded by doing either dengue NS1 on initial presentation or ICT for dengue in late presentation. But those patients who had co-infection of dengue and CHIKV were included in the study. Three groups were defined: first group of 80 viremic patients (positive CHIKV RT-PCR), second