ENDOCRINOLOGÍA Y NUTRICIÓN www.elsevier.es/ endo Endocrinol Nut r. 2011; 58(2): 62−67 1575-0922/$ - see front matter © 2010 SEEN. Published by Elsevier España, S.L. All rights reserved. ENDOCRINOLOGÍA Y NUTRICIÓN ENDOCRINOLOGÍA Y NUTRICIÓN ▶Editorial E N finalmente en MEDLINE ▶Originales Estudio de la relación entre las concentraciones plasmáticas de adiponectina, interleucina 18 y ghrelina y la densidad mineral ósea en mujeres con obesidad mórbida tras bypass gástrico Factores relacionados con la persistencia de la enfermedad a los 5 años del diagnóstico de cáncer diferenciado de tiroides: estudio de 63 pacientes ▶Revisión Mutaciones de AIP en adenomas hipofisarios familiares y esporádicos: experiencia local y revisión de la literatura ▶Notas clínicas Un efecto secundario grave: sepsis por carbimazol Remisión del hipercortisolismo tras suprarrenalectomía unilateral en paciente con enfermedad de Cushing persistente e hiperplasia adrenal macronodular Bocio amiloide secundario a enfermedad de Crohn ▶Cartas al Director Miopatía proximal secundaria a tratamiento con estatinas en paciente con tiroiditis de Hashimoto Órgano de la Sociedad Española de Endocrinología y Nutrición www.elsevier.es/endo www.seenweb.org Volumen 58 Número 1 Enero 2011 Incluída en: Index Medicus/MEDLINE, SCOPUS, EMBASE/Excerpta Medica y ScienceDirect Órgano de la Sociedad Española de Endocrinología y Nutrición ORIGINAL ARTICLE Reference values for thyroid hormones in the population of pregnant women in Jaen (Spain) Piedad Santiago a, *, María Berrio a , Pablo Olmedo b , Inés Velasco c , Baltasar Sánchez a , Eduardo García d , Julia Martínez a , Federico Soriguer d a UGC de Endocrinología, UGC de Análisis Clínicos y Servicio de Radiología, Complej o Hospit alario de Jaén, Jaén, Spain b Dist rit o Sanit ario de Jaén, Jaén, Spain c Servicio de Ginecología y Obst et ricia, Hospit al de Riot int o, Huelva, Spain d Servicio de Endocrinología, Hospit al Civil de Málaga, Málaga, Spain Received 17 October 2010; accepted 9 December 2010 *Corresponding author. E-mail address: santiago11@ono.com, piedad.santiago.sspa@juntadeandalucia.es (P. Santiago). Abstract Obj ect ive: To assess thyroid function in the three trimesters of pregnancy in healthy women taking iodine supplements and to defne the normal reference ranges in this population. Design: Descriptive study of pregnant women to defne the normal ranges of thyroid hormones in this population. Set t i ng: Jaen and Osuna (Spain). Populat ion: Healthy pregnant women. Met hods: Thyroid hormone measurement in the three trimesters of pregnancy in healthy women taking iodine supplements. Resul t s: A total of 429 pregnant women were given iodine supplements to maintain urinary iodine levels within the normal range. FT4 levels ranged from 0.60 to 1.06 ng/dL in the frst trimester, from 0.43 to 0.85 ng/dL in the second, and from 0.40 to 0.82 ng/dl in the third trimester. Reference values of thyroid stimulating hormone (TSH) ranged from 0.23 to 4.18 µIU/ mL in the frst trimester, from 1.78 to 3.89 µIU/mL in the second, and from 2.01 to 4.30 µIU/mL in the third trimester. FT3 levels ranged from 2.33 to 3.84 pg/mL in the frst trimester, from 2.04 to 3.51 pg/mL in the second, and from 1.99 to 3.46 pg/mL in the third trimester. Conclusion: Taking into account the 3rd and 97th percentiles, the reference ranges in our population were far below those recommended by our reference laboratory. In view of these results, these values should be redefned to avoid misdiagnosis of hypothyroxinemia in healthy pregnant women. © 2010 SEEN. Published by Elsevier España, S.L. All rights reserved. KEYWORDS Thyroid hormones; Pregnancy; Normal ranges; Iodine intake