Porang Glucomannan Supplementation Improves Lipid Profle in Metabolic Syndrome Induced Rats Azizah Hikma Saftri 1 *, Nurina Tyagita 1 and Taufqurrachman Nasihun 2 1 Department of Biochemistry, Medical Faculty of Sultan Agung Islamic University, Semarang, Indonesia; azizah.saftri@unissula.ac.id 2 Department of Biochemistry and Master Program of Biomedical Sciences of Sultan Agung Islamic University, Semarang, Indonesia *Author for correspondence JOURNAL OF NATURAL REMEDIES 1. Introduction Excessive calorie intake and lack of physical activity of sedentary lifestyle has been health problem in modern societies. Such lifestyle can trigger diseases such as type 2 diabetes mellitus and Cardiovascular Diseases (CVDs). Complex risk factors for Cardiovascular Diseases (CVDs) and diabetes mellitus type 2 are interrelated and ofen occur simultaneously known as Metabolic Syndrome (MetS) 1 . MetS has been a major health problem worldwide. It is estimated that 20-25 % of the world’s adult population have MetS 2 . In 2015, American Heart Association reported that the prevalence of MetS continues to increase globally 3 . Overall prevalence of MetS in the United States from the years 2003-2012 was estimated at 33%, with the higher prevalence in women than men (35.6% vs. Abstract Background: Porang glucomanan has been shown to have a potential properties for the prevention of Metabolic Syndrome (MetS). This study aimed to investigate that porang glucomannan supplementation can improve lipid profile in metabolic syndrome induced rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into 5 groups consistng a contol group standard diet (Normal); metabolic syndrome group (SM), metabolic syndrome group + 25mg/200gBW porang glucomannan (GMP25), metabolic syndrome group + 50mg/200gBW porang glucomannan (GMP50), and metabolic syndrome group + 100mg/200gBW porang glucomannan (GMP100). The lipid profle before and afer inducton with high-fat and high-carbohydrate diet, and afer 28 days of porang glucomannan supplementaton were evaluated. Data were analyzed using One Way Anova followed by LSD Post Hoc test. Results: GMP100 group showed the highest reversal of diet-induced changes, with decreased total cholesterol (TC), triglycerides (TG), and LDL, and also increased HDL level. The mean levels of TC, TG, and LDL in GMP100, GMP50 and GMP25 was signifcantly lower than those of in SM (p = 0.000), and was signifcantly higher than those of normal (p = 0.000). While the levels of HDL in GMP 100, GMP50, and GMP25 was signifcantly higher than those of SM (p = 0.000), but signifcantly lower than those of normal (p = 0.000). Conclusion: Porang glucomannan supplementaton improves lipid profle in metabolic syndrome induced rats with best dose at 100 mg/200 gBW. Keywords: Glucomannan, Lipid Profle, Metabolic Syndrome, Porang DOI: 10.18311/jnr/2017/18125