Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation Rebecca H. Chisholm, Tommaso Lorenzi, Jean Clairambault PII: S0304-4165(16)30214-8 DOI: doi: 10.1016/j.bbagen.2016.06.009 Reference: BBAGEN 28521 To appear in: BBA - General Subjects Received date: 1 April 2016 Revised date: 25 May 2016 Accepted date: 5 June 2016 Please cite this article as: Rebecca H. Chisholm, Tommaso Lorenzi, Jean Clairambault, Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation, BBA - General Subjects (2016), doi: 10.1016/j.bbagen.2016.06.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.