Global Modulation in DNA Epigenetics during Pro-Inflammatory Macrophage Activation Nikhil Jain* 1 , Tamar Shahal 2,3 , Tslil Gabrieli 3 , Noa Gilat 3 , Dmitry Torchinsky 3 , Yael Michaeli. 3 , & Viola Vogel* 1 & Yuval Ebenstein* 3 1 Laboratory of Applied Mechanobiology, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Switzerland 2 Sagol Center for the Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel. 3 Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv, 6997801, Israel. Running title: Epigenomics of macrophage activation *Co-corresponding authors Yuval Ebenstein, Department of Chemical Physics School of Chemistry Tel Aviv University Ramat Aviv 69978 Tel Aviv, Israel Office: +972-3640-8901 Lab: +972-3640-5452 uv@post.tau.ac.il certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not this version posted March 24, 2019. . https://doi.org/10.1101/587311 doi: bioRxiv preprint