_____________________________________________________________________________________________________ *Corresponding author: Email: anupama.hegde@manipal.edu; British Journal of Medicine & Medical Research 9(10): 1-7, 2015, Article no.BJMMR.18858 ISSN: 2231-0614 SCIENCEDOMAIN international www.sciencedomain.org Effect of High Normal Thyroid Stimulating Hormone Levels on Lipid Parameters in Non-diabetic Subjects T. Jaseem 1 , Anupama Hegde 1* , Poornima A. Manjrekar 1 , Chakrapani Mahabala 2 , Sathish Rao 2 and M. S. Rukmini 1 1 Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, India. 2 Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, India. Authors’ contributions This work was carried out in collaboration between all authors. Authors PAM, SR and MSR were responsible for study design, critical revision of manuscript for important intellectual content. Authors PAM and CM were responsible for study design, concept, critical revision of the manuscript, data interpretation, reviewed the draft and study supervision. Author TJ initiated the project, acquisition of data, data analysis and interpretation of the data, wrote the manuscript and had full access to all the data in the study and takes responsibility for integrity of data and the accuracy of the data. All authors read and approved the final manuscript. Article Information DOI: 10.9734/BJMMR/2015/18858 Editor(s): (1) E. Umit BAGRIACIK, Department of Immunology, Gazi University, Turkey. Reviewers: (1) Anonymous, Erzincan University, Turkey. (2) Abrão Rapoport, São Paulo University, Brazil. (3) Anonymous, Federal Urdu University of Arts Science and Technology, Pakistan. Complete Peer review History: http://sciencedomain.org/review-history/10226 Received 13 th May 2015 Accepted 4 th July 2015 Published 17 th July 2015 ABSTRACT Aim: To investigate relationship between serum TSH and lipid parameters in subjects with different levels of TSH. Study Design: Cross-sectional study. Place and Duration of Study: Clinical Biochemistry Department of Kasturba Medical College, Hospital Mangalore, between January 2014 to June 2014. Methodology: 348 subjects were screened of which 194 were selected. Lipid parameters, TSH, T 3 , T 4 and glycemic status were determined. Association between TSH and serum lipids were studied by categorizing subjects into three groups based on their thyroid status. Group 1 [TSH= 0.27-2.5 mIU/L], Group 2 [TSH= 2.6-4.12 mIU/L] and Group 3 [TSH= 4.13-9.9mIU/L].Statistical Original Research Article