Supporting Information Placental proteomics provides insights into pathophysiology of pre- eclampsia and predicts possible markers in plasma Sheon Mary ǂ , Mahesh J. Kulkarni ǂ,* , Dipankar Malakar § , Sadhana R. Joshi # , Savita S. Mehendale ± , Ashok P. Giri ǂ,* ǂ Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India § Sciex,121 Udyog Vihar, Gurgaon, Haryana, India # Department of Nutritional Medicine, Interactive Research School for Health Affairs, Pune, India ± Dept of ObGy, Bharati Hospital, Pune, India *Corresponding author: Dr. Ashok P. Giri and Dr. Mahesh J. Kulkarni Division of Biochemical Sciences, National Chemical Laboratory Homi Bhabha Road, Pune 411008, MS, India Ph: +91-20-25902237 Fax: +91-20-25902648 E-mail: ap.giri@ncl.res.in, mj.kulkarni@ncl.res.in Table of content of supporting information Experimental procedure S1: Methodology of LC-MS E for placental proteome and SWATH- MS for plasma proteome (PDF) Table S1: Raw intensity values for proteins (sheet 1) and peptides (sheet 2) of all the samples (n=50) (XLSX) Table S2: List of differentially expressed proteins (PDF) Figure S1: Protein-protein interaction network analysis on STRING software (PDF) Table S3: Gene ontology enrichment analysis using BINGO (XLSX) Table S4: List of proteins with secreted GO term from DAVID analysis (PDF) Table S5: Plasma proteome SWATH analysis in MARKER view software (XLSX) Figure S2: MRM transitions plots for individual peptides (PDF) Figure S3: [A] Total ion count of all the MRM runs [B] Graph representing coefficient of variance versus retention time of peptides [C] Test for normality for peptide intensities (PDF)