1 Comparison of disability and relapse outcomes in randomised, placebo controlled trials in relapsing multiple sclerosis: A systematic review and meta-regression Christian Röver 1 , Richard Nicholas 2 , Simon Steinvorth 1 , Sebastian Straube 3 , Tim Friede 1 1 Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany 2 Imperial College Healthcare NHS Trust, London, UK 3 Institute of Occupational, Social and Environmental Medicine, University Medical Center Göttingen, Göttingen, Germany Corresponding author: Prof Tim Friede, University Medical Center Göttingen, Department of Medical Statistics, Humboldtallee 32, D-37073 Göttingen; Tel +49-551-39 4991; Fax +49-551-39 4995; tim.friede@med.uni-goettingen.de Figures: 3 Tables: 2 Number of references: 26 Character count for title: 140 Word count: 4417 (including 198 for the abstract)