Indian J. Vet Sci. Biotech (2018) Vol. 14 No. 1 71 The Indian Journal of Veterinary Sciences & Biotechnology (2018) Volume 14, Issue 1, 71-74 ISSN (Print) : 2394-0247 : ISSN (Print and online) : 2395-1176, abbreviated as IJVSBT 10.21887/ijvsbt.v14i1.13002 Effect of Ciprofloxacin on Recovery and Conception Rate in infectious Repeat Breeder Crossbred Cows Anavil Bhardwaz 1 , S.P. Nema 1 , Sudarshan.K 1 *, Daljeet Chabbra 2 , Supriya Shukla 3 , Nidhi Shrivastava 3 and Ritika Madhwani 1 1 Department of Veterinary Gynaecology & Obstetrics, 2 Department of Veterinary Microbiology, 3 Department of Veterinary Pathology College of Veterinary Science and AH, NDVSU, Mhow (MP), India Publication Info Article history: Received : 22-01-2018 Accepted : 23-03-2018 Published : 20-07-2018 Key Words: Repeat breeders, uterine flushing, Ciprofloxacin, PMNs %, WST, Conception Rate. *Corresponding author: drsudarshandogra@yahoo.com This work is licensed under the Creative Commons Attribution International License (http:// creativecommons.org/licenses / by/4.0/P), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Copyright @: 2018 by authors and SVSBT. Abstract The present study was undertaken to evaluate the therapeutic efficacy of Ciprofloxacinin in 20 infectious repeat breeder crossbred cows brought to the AI centre of Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, Mhow and nearby Government AI centers. Animals were divided into two groups ten in each .The animals in first group were treated with Ciprofloxacin Hydrochloride @ 4 mg/kg BW IU. The animals in control group were infused with 30 ml saline IU. Bacterial count, total Cellular count and PMNs values were reduced highly significantly (P < 0.01) in Ciprofloxacin treated group than in control group. 90.00 % cows under Ciprofloxacin treatment became negative to White side test. An overall conception rate of 70.00 per cent was found in Ciprofloxacin treated repeat breeder cross bred cows. Introduction Repeat breeding alone is a major cause of infertility and economic loss to dairy farming. Reproductive tract infections, has been attributed to be one of the most important factors. The incidence of repeat breeding had been reported to vary from 7.31 to 23.88 per cent among bovines (Singh, 1991). Prasad (2006) recorded higher bacterial load prior to treatment per ml of cervical mucus in cases of endometritis. The most common method of treatment is both intrauterine (Galvao et al., 2009 and Galvao, 2011) or systemic (Chenault et al., 2004) antibiotic administration. The present study was carried out to evaluate the efficacy of ciprofloxacin I/U infusion in repeat breeder cross bred cows. Materials and Methods The study was conducted on clinical cases of cross bred cows belonging to farmers brought to the Artificial Insemination (AI) centre of