P2 &kychotic disorders andantipsychotics s313 and 9 patients met two sets of criteria. 2 patients met one set of criteria. One patient failed to fulfill any criteria. Concluakm: NMS can occur during OLA treatment. Levenson’s original criteria were more likely to diagnose OLAbinduced NMS cases than Addonizio’s criteria or even more than the strict criteria set by the APA (DSM-IV). References [l] Barnes T.R. & MC Phillips M.A. Clinical analysis and comparison of the side-effect and safety profiles of new antipsychotics. Br J Psychiatry 1999, 174 (suppl 38): 34-43. Ip.2.082J Olanzapine-associated nguroleptic malignant syndrome: Is there any oveflap with the serotonin syndrome? VI? Kontaxakis, B.J. Havaki-Kontaxaki, N.G. Christodoulou, K.G. Paplos, G.N. Christodoulou. Department of Psychiatry, University of Athens, Eginition Hospital, 74 Vm. Sophias Avenue, 11528 Athem, Greece Introduction: Neuroleptic Malignant Syndrome (NMS) is a rare but potentially fatal reaction associated with antipsychotic med- ications. There are controversies as to whether “classical” forms of NMS can occur in patients given atypical antipsychotics. Nowadays the possible relationship between NMS and Serotonin Syndrome (SS) is discussed. The aim of this phenomenological study is to examine the reported NMS’ cases induced by Olanza- pine (OLA) regarding both NMS and SS clinical features. Methods: A MEDLINE search related to definite or possible OLA-induced NMS cases reported in the international literature from January 1996 to December 1999 was conducted. On the basis of the titles and information included in the abstracts, twelve case reports were ordered. All OLA-induced NMS cases were analyzed against both NMS (DSM-K 1994) and SS (Stembach, 1991) clinical features. Results: NMS - associated with OLA developed in nine males (mean age 39.9 f 19.3 years, range 21-69) and in three females (mean age 56.6 f 15.2, range 40-70). Schizophrenia was the primary diagnosis in six of the patients (50%). The mean OLA dosage was 10.8 f 7.8 mgday (range 5-25 mgday). The common clinical features in both NMS and SS are fever, mental status changes, diaphoresis and tremor. All the above four clinical fea- tures were concurrently presented in three patients (25%). Three out of the ten SS clinical features set by Stembach were con- currently observed in seven (58%) patients. Four clinical features were observed in five (42%) patients and 5 clinical features in 2 (17%) patients. The SS clinical features presented in cases diag- nosed as NMS were fever (83%), mental status changes (75%), diaphoresis (58%), tremor (33%), agitation (17%), incoordination (17%), hyperreflexia (17%), and incontinence (8%). Conclusion: The present results show that the clinical symp- toms of both OLA-induced NMS and’ SS are overlapping. The hypothesis that the two syndromes are non-specific and may share the same underlying pathophysiology i$ reinforced. References [l] Fink M. Toxic serotonin syndrome or nenroleptic malignant syndrome? Pharmacopsychiatry 1996,29: 159-161. [2] Nisijima K. Abnormal monoamine metabolism in cerebrospinal fluid in a case of serntonth syndrome. J Clin Psychoph~ logy iOoo,20, 1: 107-108. lp.2.0831 Depression measures and motor side-effects among schizophnriic inpatients VP. Kontaxakis, B.J. Havaki-Kontaxaki, S. Stamouli, M. Margariti, C. Kollias, G.N. Christodoulou. Department of Psychiahy. University of Athens, Eginition Hospital, 74 tis. Sophias Ave., 11528 Athens, Greece Introduction: There is evidence of an overlap between depres- sion and neuroleptic-induced extrapyramidal symptoms among schizophrenic patients. The aim of this study is to evaluate the associations between three measures of depression and motor side- effects in acute schizophrenic inpatients. Methods: Sixty four acute schizophreuic inpatients (39 men) with a mean age of 30.3 (f8.9) years, consecutively admitted at the Eginition Hospital, Athens, were studied. Patients were assessed on admission (during the 8rst week) on the following scales: the Hamilton Depression Rating Scale (HDRS), the Posi- tive and Negative Syndrome Scale-Depression subscale (PANSS- D), the Expanded Brief Psychiatric Rating Scale-Depression sub- scale (EBPRS-D), the Rating Scale for Extrapyramidal Side- Effects (RSES), the Barnes Akathisia Rating Scale (BARS), the Abnormal Involuntary Movement Scale (AIMS). For the statistical evaluation, Pearson product moment correlations were carried out using the SPSS software. Results: There were no significant correlations between the scores of the PANSS-D or the EBPRS-D and the scores on the scales measuring extrapyramidal side-effects (RSES), akathisia (BARS) or invohmtary movements (AIMS). Besides, there were no signiticant correlations between HDRS score and the scores on the RSES or on the AIMS. However, significant correlation was found between HDRS score and the score on the BARS (r = 0.399, p < 0.01). Conclusion: The overlap found between depression measured by the HDRS and akathisia should be considered as a confounding factor in the research level. References [I] Presser ES., Csernasky LG., Kaplan J., Thiemamr 8, Becker T.J.,Hol- lister L.E. Depression, parkinsonian symptoms, and negative symptoms in schizophrenics treated v&h nenroleptics. J Nerv Ment Dis 1987, 175: 10&105: [2] Snaith P What do depression rating scales measure? Br J Psychiatry 1993, 163: 293-298. lp.2.0841 the use of atypical antlpsychotics in the University Psychiatric Hospttal in Athens VI? Kontaxakis, B.J. Havaki-Kontaxaki, C. Kollias, S. Stamouli, M. Margariti, G.N. Christodoulou. Department of Psychiatry, University of Athens, Eginition Hospital, 74 KU. Sophias Ave., 1 I528 Athens, Greece Introduction: The rapid changes in the pharmacotherapy of schizophrenia and the introduction of atypical antipsychotics led to the re-evaluation of the treatment strategies. The aim of this prospective study is to elucidate the atypical antipsychotics pre- scribing practices concerning acute schizophrenic inpatients. Methods: The study group consisted of 82 schizophrenic pa- tients (61% men) consecutively admitted at Eginition Hospital, DqmrWant of Psychiatry, University of Athens, during one year period (Wruary 1997 to March 1998). Their mean age was 30.9