290 A Retrospective Cohort Study in a University Hospital Evaluating the Effect of Maternal Glucose- Containing Intravenous Fluid in Neonatal Glycemia Gelinemae G. Malaza, M.D. 1 , Elaine C. Cunanan, M.D. 1,2  Gelinemae Malaza ggm2185@yahoo.com 1 Section of Endocrinology, Department of Internal Medicine, University of Santo Tomas Hospital, Manila, Philippines 2 Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines Abstract Maternal hyperglycemia during the peri- partum period is highly correlated with fetal hyperin- sulinemia and consequent neonatal hypoglycemia. Liberal use of intravenous glucose therapy prior to delivery can potentially cause maternal hyperglyce- mia, therefore, it is prudent to implement all preven- tive measures. This study aims to determine the occurrence of ne- onatal hypoglycemia with intravenous glucose ther- apy prior to delivery in maternal diabetes mellitus. This was a retrospective cohort study of neonates born from diabetic mothers at the University of Santo Tomas Hospital Clinical and Private Divisions from January 1, 2013 to December 15, 2017. Clinical information gathered was divided into maternal and neonatal characteristics. Maternal intravenous fuid use, rate, and duration were noted; maternal and neonatal blood glucose results were obtained. There were 109 infants of diabetic mothers, of which 105 were delivered as singleton and 4 from twin pregnancies. Neonatal hypoglycemia was present in 14.68%. Comparing the risk factors, there was a higher amount of glucose infused to the moth- ers whose offspring developed hypoglycemia com- pared to those without hypoglycemia. Statistically, this did not demonstrate a signifcant difference. The rate of glucose infusion and frequency of maternal insulin use were similar between the groups. Linear correlation was not evident when the total glucose infused and the rate of intravenous glucose infusion was compared to the neonatal glucose in the frst hour of life. Based on this study, routine administration of glu- cose-containing intravenous fuid did not infuence the incidence of neonatal hypoglycemia. It is rec- ommended that further prospective studies be con- ducted. Keywords gestational diabetes mellitus, neonatal hypoglycemia, intravenous fuid INTRODUCTION Maternal diabetes mellitus is associated with in- creased risk of fetal and neonatal complications, with neonatal hypoglycemia occurring in 8% to 30% [1]. Neonatal hypoglycemia screening in all newborns from diabetic mothers is mandatory because of its