                     Robin Cornelissen M.D., Ph.D. 1 ; Joost P.J.J Hegmans Ph.D. 1 ; Alexander P.W.M. Maat M.D. 2 ; Margaretha E.H. Kaijen"Lambers 1 ; Koen Bezemer 1 ; Rudi W. Hendriks Ph.D. 1 ; Henk C. Hoogsteden M.D. Ph.D. 1 ; and Joachim G.J.V. Aerts M.D., Ph.D. 1,3 1 Department of Pulmonary Medicine, Erasmus MC Cancer Institute, Rotterdam, The Netherlands 2 Department of Cardio"Thoracic Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands 3 Department of Pulmonary Medicine , Amphia Hospital, Breda, The Netherlands   Joachim Aerts Erasmus MC Cancer Institute Department of Pulmonary Medicine, Room H"Ee2218 P.O."box 1738 3000 DR, Rotterdam, The Netherlands Phone +31 10 704 3697 Fax: +31 10 704 4728 Page 1 of 40 AJRCCM Articles in Press. Published on 14-December-2015 as 10.1164/rccm.201508-1573OC Copyright © 2015 by the American Thoracic Society