International Journal of Basic & Clinical Pharmacology | July 2020 | Vol 9 | Issue 7 Page 1090 International Journal of Basic & Clinical Pharmacology Singh S et al. Int J Basic Clin Pharmacol. 2020 Jul;9(7):1090-1094 http://www.ijbcp.com pISSN 2319-2003 | eISSN 2279-0780 Original Research Article Evaluation of hematological parameters in oral cancer and oral pre-cancer Shruti Singh 1 , Jaya Singh 1 , Fahad Mansoor Samadi 1 *, Shaleen Chandra 1 , Roop Ganguly 2 , Shaista Suhail 1 INTRODUCTION Oral cancer reports for approximately 3% of all malignancies and affects 2,70,000 patients annually worldwide. 1 It is noteworthy that majority of the oral cancer derived from oral precancerous lesions such as leukoplakia, oral submucous fibrosis, amongst others. 1 Oral pre-cancer lesions have quite high malignant transformation rate. 2 Numerous biomarkers are have been studied in order to provide early diagnosis and treatment, thus better survival rate of the patients. 3 Many attempts have been done on blood biochemistry and hematology to explore the etiology of cancers and to establish this as tumor markers. Quantitative alteration in the serum during tumor initiation and progression takes place. Thus, authors aim to study the haematological DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20202947 1 Department of Oral Pathology and Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, India 2 Department of Oral and Maxillofacial Surgery, King George’s Medical University, Uttar Pradesh, India Received: 04 April 2020 Revised: 14 May 2020 Accepted: 15 May 2020 *Correspondence: Dr. Fahad Mansoor Samadi, Email: oralpathresearch1@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Oral squamous cell carcinoma (OSCC) is the most common public health issue in Indian population. Quite a large number of OSCC cases are preceded by potentially malignant disorders of oral cavity. The need for simple diagnostic marker for early diagnosis and thus better therapeutic outcome is imperative. The current study aims to evaluate hematological parameters such as hemoglobin, bleeding time, clotting time, total leucocyte count (TLC) and differential leucocyte count (DLC) in OSCC and oral potentially malignant disorder cases along with normal healthy controls. Methods: A total of 150 subjects; 50 in each group were taken and 2.5 ml of blood were withdrawn from each subject and TLC, DLC and hemoglobin assessment was done using autoanalyzer while bleeding time and clotting time was recorded through Duke’s method and modified Dale’s method respectively. Results: All the data were tabulated and recorded as mean±standard deviation and comparison was done using one- way ANOVA test (p<0.05). TLC count, neutrophil count and lymphocyte count showed statistically significant difference amongst three groups while other parameters such as hemoglobin percentage, bleeding time, clotting time, eosinophil count, monocyte count and basophil count were statistically non-significant. Conclusions: This study showed TLC count, neutrophil count and lymphocyte count might prove as useful determinant factor in oral squamous cell carcinoma and oral potentially malignant disorders. However, further study with larger sample size is required to establish their role as diagnostic, prognostic marker or predictor of malignant transformation. Keywords: Bleeding time, Clotting time, Haemoglobin, Hematological, Differential leucocyte count, Oral potentially malignant disorders of oral cavity, Oral squamous cell carcinoma, Total leucocyte count