442 Free Papers—Oral Presentations Department of Oral and Maxillofacial Surgery, Cardiff University Dental Hospital, Heath Park, Cardiff, United Kingdom A 10-year retrospective review of oral cancer treatment at the maxillofacial unit Cardiff is presented. Utilising the Walton database, the stage of the disease at pre- sentation, the resection and the type of neck dissection performed, the method of reconstruction and the primary site and neck recurrence as well as survival rates are presented. There is a follow up period of between 2 and 12 years. A previous presentation with a subsequent published paper by the senior author emphasised the shortcomings of the supraomohyoid neck dissection and the need for the inclusion of level IV and this presentation will support these views. doi:10.1016/j.ijom.2009.03.163 O2.32 Total palatal reconstruction—fact or fiction C.V. Thomas * , M.J. Fardy, A. Cronin, A. McGroary Department of Oral and Maxillofacial Surgery, Cardiff University Dental Hospital, Heath Park, Cardiff, United Kingdom The aim of total palatal reconstruction is to provide a structure on which the patient can return to swallowing and have good speech. We would like to describe experience of senior authors with this difficult problem. In particular we will review the surgical technique in applying a radial forearm flap to achieve a two layer closure with skin coverage on the nasal as well as the oral side on 25 patients. We will describe the pre- and postoperative results in relation to speech and swallowing. doi:10.1016/j.ijom.2009.03.164 O2.33 O-(2-[F-18]fluorethyl)-L-tyrosine positron emission tomography in the diagnosis of head and neck cancer: increased amino acid transporter expression in squamous cell carcinomas A. Zimmermann * , D. Salber, G. Stoffels, S. Klein, D. Pauleit, N.R. K ¨ ubler, K. Hamacher, H.H. Coenen, K.J. Langen Department of Maxillofacial and Facial Plastic Surgery, University Hospital, Heinrich-Heine University, Dusseldorf, Germany Background and Objectives: O-(2-[F- 18]fluorethyl)-L-tyrosine (FET) is useful in brain tumour diagnostics and also shows high uptake in squamous cell carci- nomas (SCC). In contrast to the standard positron emission tomography (PET) tracer [ 18 F]fluorodeoxyglucose (FDG) in head and neck tumour imaging, with FET a differentiation between tumour and inflammatory tissue seems possible. It is assumed that this special uptake behaviour is caused by selective transport of FET via the LAT2 subtype of the system L amino acid transporter. Methods: Seven patients with head-neck tumours had FDG and FET whole body PET. In the subsequent operation 14 tis- sue probes were taken from FDG positive tumour or lymph node metastases. Six of the 14 lesions were FET positive. Expression of the system L Amino acid transporter subtypes LAT1 and LAT2 as well as the heterodimer CD98 that is rel- evant for functional expression of both transporter subtypes was measured using real-time polymerase chain reaction. Results: Increased LAT2/CD98- expression was found in 5 of 6 FET positive tumour probes while all FET negative tumours exhibited low LAT2- transporter expression. High LAT1 expression was observed in 6 out of 14 tissue probes, 3 of which were FET nega- tive. Furthermore, 3 of the 6 FET positive tumour probes had low LAT1 expression. Conclusions: The results confirm the hypothesis that FET accumulation is related to the expression of the LAT2 sub- type of system L amino acid transporter, which is overexpressed in SCC but not in inflammatory tissue. doi:10.1016/j.ijom.2009.03.165 O3: Cleft Lip and Palate/ Craniofacial Surgery O3.1 Anthropometric and gradation of alar base and maxillary bone of uilateral cleft lip secondary nasal deformity Z. Lei Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China Background and Objectives: The study was conducted to measure the alar base and maxillary bone of unilateral cleft lip sec- ondary nasal deformity and to investigate the satisfaction of patients, in order to gradate the depression of alar base and pro- vide reference for the clinical surgery. Methods: Thirty patients had been treated in the past six months at the Depart- ment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University. The posterior-anterior films, lateral projection and three-dimensional computed tomography (CT) taken before surgery, and the data of noses before and after surgery were analysed for the relationship of soft tissues and maxillary bones. Gradation of alar base was also made based on these data. Results: In all cases, the cleft-side piriform margin was downward, abduction and depression. The position of alar base was related to the piriform morphous. However, in contrast with bony position, the cleft-side alar base was located more upward than the non-cleft side alar base in 10 of 30 patients, located more endoduc- tion than the non-cleft side alar base in 12 of 30 patients and located more anteriorly than the non-cleft side alar base in 20 of 30 patients. The satisfaction of nose had more relation- ships with skewness of dorsum of nose, skewness of nasal columella, symmetry of nostrils and the depression of alar base. When the depression was <4 mm, we obtained a fine appearance of nose only through the repair of soft tissues; When the depression was ≥4 mm, we had to combine with graft or the restitution of cleft of alveolus. There was no difference between the results from X-ray and three-dimensional CT when we measured the piriform of uilateral cleft lip secondary nasal deformity. Conclusions: The growth of maxillary bone for the patients with cleft lip and palate was insufficient. Bony depression did not necessarily lead to postoperative alar depression, and the alar base can be adjusted to a suitable place through the operation. Anthropometry of nose was important before surgery in order to choose the methods and got the satisfaction. doi:10.1016/j.ijom.2009.03.166 O3.2 Technique for surgical tongue reduction in Beckwith- Weidemann syndrome macroglossia J.E. Portnof Department of Plastic and Maxillofacial Surgery, Royal Children’s Hospital of Melbourne, Parkville Victoria, Australia Background and Objectives: Beckwith Weidemann syndrome (BWS) is a rare