Critical Reviews in Oncology/Hematology, 1992; 13~55-11 0 1992 Elsevier Science Publishers B.V. All rights reserved. 1040-8428/92/$15.00 55 ONCHEM 00029 Non-Hodgkin’s lymphomas in children. I. Patterns of disease and classification Les White”, Stuart E. Siegelb and T.C. Quah” “Oncology Programme. Prince of W ales Children S Hospital, University of New South W ales, Sydney, NS W , Australia. bDivision of Hematology-Oncology, Children k Hospital of Los Angeles, University of Southern California. Los Angeles, CA, USA and ‘Department of Paediatrics. National University Hospital. Singapore (Accepted 20 March 1992) zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIH Contents I. II. III. IV. V. VI. VII. VIII. IX. X. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 Pathology ............................................... A. Histology and cytology ................................... B. Immunophenotyping ..................................... Primary sites of disease ..................................... A. Abdomen ............................................ B. Mediastinum ........................................... C. Head andneck ........................................ D. Other primary sites ...................................... Burkitt’s lymphoma ......................................... 62 A. Epidemiologic and clinical aspects .......................... 63 B. Laboratory findings ..................................... 63 Bone marrow involvement in NHL Involvement of the central nervous system 63 Diagnosis, staging and monitoring . 65 Patterns of relapse . . Cytogenetics and molecular biology 66 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 56 56 58 59 59 59 61 62 63 66 References . . . . . . . ..~........~..~..~..~~~...~~~~~..~..~~.~.......~~....~..~ 68 Corre.~/~~ndrrlc,~ IO: Dr. Les White. Pediatric Oncology, Prince of Wales Children’s Hospital, High Street, Randwick, New South Wales. 2031, Australia.