Dr Arjun Baidya et al JMSCR Volume 06 Issue 04 April 2018 Page 409 JMSCR Vol||06||Issue||04||Page 409-415||April 2018 Study of comparative effect of hydroxychloroquine and vildagliptin on glycaemic efficacy and HbA1cin type 2 diabetes patients who were inadequately controlled with metformin and glimepiride dual therapy Authors Dr Arjun Baidya 1 , Dr Manish Kumar 2 , Dr Shailesh Kumar Pathak 3 , Dr Rishad Ahmed 4 1 Department of Endocrinology, Nil Ratan Sircar Medical College & Hospital, Kolkata, West Bengal, India 2 Department of Medicine, Patna Medical College & Hospital, Patna, Bihar, India 3 Department of Medicine, Patna Medical College & Hospital, Patna, Bihar, India 4 Department of Medicine, KPC Medical College, Kolkata, West Bengal, India Corresponding Author Arjun Baidya Department of Endocrinology, Nil Ratan Sircar Medical College and Hospital, 138, AJC Bose Road, Kolkata, West Bengal 700014, India Email: arjun.baidya@gmail.com Abstract Objective: The objective of this study is investigate the glycaemic efficacy parameters of hydroxychloroquine (HCQ) in comparison to those of vildagliptin in uncontrolled type 2 diabetes mellitus (T2DM) patients who were inadequately controlled with metformin and glimepiride dual therapy. Methods: Uncontrolled type 2 diabetes patients with glycated haemoglobin (HbA1c) of 7.0–9.0% and on metformin up to 1000 mg/day along with glimepiride up to 2 mg/day were selected for the study. Hundred eligible patients were randomly divided into two groups. One group comprises of 50 patients whose baseline fasting plasma glucose (FPG), post prandial plasma glucose (PPPG), HbA1c were determined and the patients were put on hydroxychloroquine 400 mg per day apart from metformin 1gm /day and glimepiride 2mg/day, another group comprises of 50 patients whose baseline FPG, PPPG, HbA1c were determined and put on vildagliptin 100 mg per day apart from metformin 1gm /day and glimepiride 2mg/day. At 3 months and 6 months, levels of glycaemic parameters were compared with those at baseline. Results: At 3 months, while similar reductions of glycated hemoglobin (HbA1c) levels were observed with these two drugs, after 24 weeks of treatment with hydroxychloroquine 400mg, metformin and glimepiride, subjects had greater reduction in FPG, PPPG and HbA1c as compared to vildagliptin, glimepiride and metformin. Conclusion: This study showed that hydroxychloroquine can be an effective alternative to DPP4 inhibitors like vildagliptin for add on therapy to the patients who are inadequately controlled with metformin and glimepiride dual therapy. Keywords: Glycemic efficacy, HbA1c, Hydroxychloroquine, Type2 diabetes, Vildagliptin. Introduction T2DM is a long term metabolic disorder that is characterized by high blood glucose, insulin resistance, and relative lack of insulin. It is due to insufficient insulin production from beta cells in the setting of insulin resistance 1 . Insulin www.jmscr.igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 71.58 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v6i4.68