_______________________________________________________________________________________________________________________________ 3852 https://www.id-press.eu/mjms/index ID Design Press, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2019 Nov 30; 7(22):3852-3855. https://doi.org/10.3889/oamjms.2019.518 eISSN: 1857-9655 Herbal Medicine in Pharmaceutical and Clinical Sciences Mikania Micrantha Improved Memory Perform on Dementia Model Yuni Andriani * , Siti Hamidatulaliyah, Desi Sagita, Muhammad Aminuddin Department of Pharmacology and Clinical Pharmacy, Department of Pharmaceutical Biology, Health Institute of Harapan Ibu Jambi, Jambi, Indonesia 36132 Citation: Andriani Y, Hamidatulaliyah S, Sagita D, Aminuddin M. Mikania Micrantha Improved Memory Perform on Dementia Model. Open Access Maced J Med Sci. 2019 Nov 30; 7(22):3852-3855. https://doi.org/10.3889/oamjms.2019.518 Keywords: Mikania micrantha; Dimentia; Memory; RAM; Alloxan *Correspondence: Yuni Andriani. Department of Pharmacology and Clinical Pharmacy, Department of Pharmaceutical Biology, Health Institute of Harapan Ibu Jambi, Jambi, Indonesia 36132. E-mail: yuni23_fmasi@yahoo.com Received: 25-Sep-2019; Revised: 17-Oct-2019; Accepted: 18-Oct-2019; Online first: 14-Nov-2019 Copyright: © 2019 Yuni Andriani, Siti Hamidatulaliyah, Desi Sagita, Muhammad Aminuddin. This is an open- access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) Funding: This research did not receive any financial support Competing Interests: The authors have declared that no competing interests exist Abstract BACKGROUND: The purpose of this research is to explore the existing natural resources in Jambi province which has potential as anti-dementia agent. So that will be many natural resources that can be a potential product in reducing the unwanted effects of dementia as a degenerative disorder that is currently an inevitable elderly disease. by investigating with various plants in Jambi that have activities as anti-dementia is expected more and more natural resources that can be used as neuron-protection and or neuron-curative. AIM: The purpose of this study is to find plants and / or compounds that are useful as neuroprotection METHODS: Dementia model is formed by diabetic test animals. The test group consisted of extract group, three fractions (hexane, ethyl acetate and butanol fraction at dose 500 mg/Kg BB p.o) and one group of antidiabetic drugs glibenclamide, and the group of normal animal test animals was tested with Radial arm maze (RAM) for seven days before alloxan induced to obtain dementia model. RESULTS: The results showed that extract and ethyl acetate fraction at dose 500 mg/Kg BW gave a positive effect on memory improvement based on animal performance on RAM tool during a testing time (P < 0, 05) with LSD statistical analysis. CONCLUSION: The extract and ethyl acetate fraction of Mikania micrantha showed good potential for improving the performance of animal memory in RAM devices representing dementia models. Introduction Dementia is a neurodegenerative disease that is linearly correlated with aging [1]. The incidence is reduced by age below 60 years. Dementia is characterized by a decrease in cognitive and behavioral function. Dementia is also a marker of progressive destruction of the brain's physiological function, Alzheimer's is one of the most frightening forms of dementia, hence numerous studies have been conducted both in vivo and in vitro to know more about the pathological path of dementia so that scientists can know how to prevent and treat the condition. Recent studies have shown a link between the incidence of diabetes mellitus (DM) [2], [3], [4] and an increased risk factor for the occurrence of dementia. Dementia in diabetic patients is associated with an impairment of brain insulin receptors leading to a decrease in cognitive function (learning and remembering) and behavioral alterations presumably caused by cerebral inflammation [5], [6], [7]. Cucumber plant (Mikania micrantha K), which is a plant of the genus Asteracea, which until now only 42 species of plant families have been experiments on biological activity. Where the plant has anti- inflammatory, analgesic, anti-bacterial, anti-protozoa, antioxidant and cytotoxic. Recent research also mentions that mikania micrantha cultivation can be used for depression conditions. Therefore, in this study, we will conduct an investigation of anti- dementia activity test from mikania plant to animal model of diabetes mellitus which in induction alloxan.