488 PEPSIN/RENIN INHIBITOR COMPLEX ANI)REI-VA, N. S., ZI)ANOV, A. S., GUSTCHINA, A. E. & FI-DOROV, A. A. (1984). J. Biol. Chem. 259, !1353-11365. BERNAI., J. D. & CROWE(X)T, D. (1934). Nature (London), 133, 794-795. BLUNDELL, T., C(X)PER, J. B., FOUNDLING, S. I., JONES, D. M., ATRASH, B. &, SZELKF, M. (1987). Biochemistry, 26, 5585 5590. BLUNDELL, T., JENKINS, J., PEARL, L., SISWELL, T. J., COOPER, J. B., TICKL1-, I. J., VEERAPANDIAN, B. & WOOD, S. P. (1990). J. Mol Biol. 211,919 941. BIAJNI)H,I,, T. L., SEWELL, B. T. & MCLA('HLAN, A. D. (1979). Biochim. Biophys. Acta, 580, 24--31. BOLLS, G. & GREER, J. (1989). Computer-AMed Drug Design. Methods and Applications, edited by T. J. PERUN & C. L. PROPST, pp. 297-326. New York: Dekker. BOTT, R., SUBRAMANIAN, E. & DAVIES, D. R. (1982). Biochemistry, 21, 6956-6962. BRONGER, A. T., KARPLtJS, M. & PF.TSKO, G. A. (1989). Acta Crvst. A45, 50 61. CItEN, L. & ABAD-ZAPATERO,C. (1992). In preparation. C(X)PER, J. B., KHAN, G., TAYLOR, G., TICKI.t-, I. J. & BIAJNDEI.L, T. L. (1990). J. Mol. Biol. 214, 199 222. ('RAVEN, B. M. (1975). ROTRAN. Univ. of Pittsburgh, USA. CROWTHER, R. A. & BLOw, D. W. (1967). Acta Crvst. 23, 544--548. CYC;I.ER, M. & ANt)ERSON, W. F. (1988a). Acta Crvst. A44, 38 45. CYGI.I-R, M. & ANI)ERS()N, W. F. (1988h). Acta Crvsc A44, 300 308. DAVIES, D. R. (1990). Annu. Rev. Biophys. Biophys. Chem. 19, 189 215. FITZC;rRALD. P. M. D. (1988). J. Appl. Cryst. 21, 273 278. I:()tJNI)I.IN(;, S. I., CO()I'ER, J., WAISON, F. E., CI,IiASBY, A., PEARL, L. H., SIBANDA, B. L., HEMMINGS. A., W(X)D, S. P., BI,UNI)EI.I,, T. L., VAI.I,ER, M. J., NOREY, C. G., KAY, J., BOGER, J., DUNN, 13. M., LECKIE, B. J., JoYl-S, D. M., ATRASII, B., HAI.I.E'I'T, A. & SZIiLKE, M. (1987). Nature (London), 327, 349-352. Hsu, I., I)EI_BAERE, L. T. J., JAMES, M. N. G. & FhnMANN, T. (1977). Nature (Lomhm), 266, 140-145. HUTCHINS, C. & GRFER, J. (1991). Crit. Rev. Biochem. Mol. Biol. 26, 77 127. JAMES, M. N. G. & SIELEC'Kk A. R. (1983). ,1. Mol. Biol. 163. 299- 361. KABSCII, W. & SANI)ER, C. (1983). Biopolymer.s, 22, 2577 2637. KOSTKA, V. (1985). Editor. Aspartic Proteinases and Their blhihi- tors, Proceedings of the FEBS Advanced Course No. 84/07, Prague, Czechoslovakia. New York: Walter de Gruyter. LATTMAN, E. E. & LOVE, W. E. (1972). Acta Cryst. B26, 1854 1857. Mli,LER, M., JASKOI,SKI, M., RAO, J. K. M., LEts, J. & WLODAWER, A. (1989). Nature (London), 337, 576-579. Molecular Structure Corporation (1989). TEXSA N. Singh, Crystal Structure Determ&ation Software. Version 5.0. MSC, The Woodlands, Texas, USA. NAWA, M. A., FITZ(it-RALI), P. M. D., MCKEI:VER, B. M., LEU, C.-T., HEIMBACII.,J. C., HERBFR, W. K., SIGAI,, I. S., DARKI-, P. L. & SPRINGER, J. P. (1989). Nature (London), 337, 615 620. NORTHROP, J. H. (1946). J. Gen. Physiol. 30, 177-184. RAO, G. K. M., ERICKSON, J. W. & WLODAWER, A. (1991). Biochemisto', 30, 4663 4671. ROSSMANN, M. G. (1972). Editor. The Moh, cular Replacement Method. New York: Gordon and Breach. R0('IIEL, R. (1981). Biochim. Biophys. Acta, 659, 99 113. SALI, A., VEERAI'ANI)IAN, B., C(X)i'IR, J. B., FOUNI)LING, S. I., HOOVER, D. J. & BI,UNDI-LL, T. L. (1989). EMBO J. 8, 2179- 2188. SIIAM, H. L., BoI,IS, G., STHN, H. H., I:ESIK, S. W., MAR('OTTI-, P. A., PI.ArTNER, J. J., REMI'EL, (7. A. & GREER, J. (1988). J. Med. Chem. 31,289 295. SilERII:I:, S., PAI)I,ANI), E. A., COttI-N, G. H. & DAVII-S, D. R. (1990). Acta Crysl. B46, 418 425. SIELEC'Kk A. R., FI;DOROV, A. A., BOODH(×), A., ANDRI'I-VA,N. S. & JAMES, M. N. G. (1990). J. Mol. Biol. 214. 143 170. SnLI-('KI, A. R., FUJINAGA, M., READ, R. J. & JAMES, M. N. G. (1991). J. Mol. Biol. 49, 671 692. S rHGEMANN, W. (1974). PhD Thesis. Tcchnische Univ., Miinchcn, Germany. SU(;UNA, K., B()II, R. R., PAI)I.AN. E. A., SUBRAMANIAN, E., SIIERIH:, S., COllEN, G. H. & DAVH-S, D. R. (1987). J. Mol. Biol. 196. 877-900. SU(;UNA, K., PADLAN, E. A., SMITH, C. W., CARl,SON, W. D. & DAVIES, D. R. (1987). Proc. Natl Acad. Sci. USA. 84, 7009- 7013. TAN(;, J., JAMI-S, M. N. G., Hsu, I. N., JENKINS, J. A. & BLUNI)H,I,, T. L. (1978). Nature (Lomhm), 271, 618 621. VI'ERAPANI)IAN, B., C(X)PER, J. B., SAt, I, A. ¢~ BI,UNI)i-LL, T. L. (1990). J. Mol. Biol. 216, 1017 1029. WI,OI)AWER, A., Mlt,LI-R, M., JASK()LSKI, M.. SATIIYANARAYANA, B. K., BAI.I)WIN, E. T.. WEBliR, I. T., Slil.K, L. M.. CLAWS()N, L., SCHNEIDER, J. & KENT, S. B. H. (1989). Science, 245, 616-621. Acta Cryst. (1992). B48, 488-492 Crystal and Molecular Structures of Propanediamine Complexed with L- and DL- Glutamic Acid: Effect of Chirality on Propanediamine BY S. RAMASWAMY AND M. R. N. MURTHY Molecular Biophysics Unit, Indian hlstitute of Science, Bangalore 560012, India (Received 6 August 1991; accepted 13 January 1992) Abstract The structures of complexes of 1,3-diaminopropanc with L- and Dl,-glutamic acid have been determined. t,-Glutamic acid complex: C3H~2N~.2CsH~NO4, 0108-7681/92.'040488-05506.00 Mr = 368.4, orthorhombic, P2~2~2~, a = 5.199 (1), h = 16.832(1), c =20.076(3)&, V= 1756.6 (4) A 3, Z =4, D,= 1.39gcm 3 A(MoKa)=0.7107A, #= 1.1 cm ~, F(000)=792, T=296K, R=0.044 for 1276 observed reflections. DL-Glutamic acid corn- © 1992 International Union of Crystallography