Jurnal Kardiologi Indonesia J Kardiol Indones. 2015;36:22-7 ISSN 0126/3773 22 Jurnal Kardiologi Indonesia • Vol. 36, No. 1 • Januari - Maret 2015 Clinical Research Polysaccharide Peptide: A promising Anti Inflammation and Anti Oxidant in Atherosclerosis Indra Prasetya 1 , Ria Ashriyah 1 , Ira Setyawati 1 , Joko Hermawan 1 , Widyo Mahargo 1 , Yunita Leksono 1 , Titin Andri W. 2 , Teuku Heriansyah 3 , Muhammad Aris W. 4 , Djanggan Sargowo 1,5 Background : Heart disease is the leading cause of death for both men and women, but heart disease is preventable and controllable. Ganoderma lucidum is widely used as traditional medicine for centuries particularly in China, Japan, and Korea. Previous study showed antioxidative activity of polysaccharide peptide (PsP) from Genoderma lucidum. Objective : This study was aimed to evaluate anti-infammatory and anti- oxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerotic rats. Methods : The atherosclerotic rats were randomly divided into four groups (5 rats each group) : atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/ kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6 , IL - 10, hsCRP, TNF - α, lipid profle and foam cell. Results : After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease signifcantly. PsSP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) de- scriptively at PsP doses 150 mg/kgBW. While the levels of TNF-α (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profle by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of athero- genesis signifcantly decreased by administration of PsP . Conclusion : PSP can be useful to reduce infammatory processes and oxidative stress to prevent the process of atherogenesis . (J Kardiol Indones. 2015;36:22-7) Keywords: polysaccharide peptide (Ganoderma lucidum), anti infammation, anti oxidant, cardiovascular disease, atherosclerotic. 1 Department of Cardiology and Vas- cular Medicine, Faculty of Medicine, Brawijaya University / Dr. Saiful An- war Hospital, Malang, 2 Department of Nursery, Faculty of Medicine, Brawijaya University, Malang, 3 De- partment of Cardiology and Vascular Medicine, Faculty of Medicine, Syiah Kuala University / Dr. Zainoel Abidin Hospital, Banda Aceh, 4 Department of Pharmacology and Pharmacother- apy, Faculty of Medicine University of Brawijaya, Malang, 5 Department of Internal Medicine, Faculty of Medi- cine, Brawijaya University / Dr. Saiful Anwar Hospital, Malang.