Research Article Carotid Intima Media Thickness Reference Intervals for a Healthy Argentinean Population Aged 11–81 Years Alejandro Diaz , 1 Daniel Bia, 2 Yanina Zócalo , 2 Hugo Manterola, 3 Ignacio Larrabide, 3 Lucas Lo Vercio, 3 Mariana Del Fresno, 3 and Edmundo Cabrera Fischer 4 1 Instituto de Investigaci´ on en Ciencias de la Salud, UNICEN, CONICET, Tandil, Argentina 2 Physiology Department, School of Medicine, Centro Universitario de Investigaci´ on, Innovaci´ on y Diagn´ ostico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800 Montevideo, Uruguay 3 PLADEMA, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina 4 Instituto de Medicina Traslacional, Trasplante y Bioingenier´ ıa (IMETTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina Correspondence should be addressed to Alejandro Diaz; alejandrounicen@gmail.com Received 22 November 2017; Revised 29 December 2017; Accepted 15 January 2018; Published 14 February 2018 Academic Editor: Franco Veglio Copyright © 2018 Alejandro Diaz et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Reference intervals (RIs) of carotid intima media thickness (CIMT) from large healthy population are still lacking in Latin America. Te aim of this study was to determine CIMT RIs in a cohort of 1012 healthy subjects from Argentina. We evaluated if RIs for males and females and for lef and right carotids were necessary. Second, mean and standard deviation (SD) age-related equations were obtained for lef, right, and average (lef + right)/2) CIMT using parametric regression methods based on fractional polynomials, in order to obtain age-specifc percentiles curves. Age-specifc percentile curves were obtained. Males showed higher A-CIMT (0.577 ± 0.003 mm versus 0.566 ± 0.004 mm,  = 0.039) in comparison with females. For males, the equations were as follows: A-CIMT mean = 0.42 + 8.14 × 10 −5 ∗ Age 2 ; A-CIMT SD = 5.9 × 10 −2 + 1.09 × 10 −5 ∗ Age 2 . For females, they were as follows: A-CIMT mean = 0.40 + 8.20 × 10 −5 ∗ Age 2 ; A-CIMT SD = 4.67 × 10 −2 + 1.63 × 10 −5 ∗ Age 2 . Our study provides the largest database concerning RIs of CIMT in healthy people in Argentina. Specifc RIs and percentiles of CIMT for children, adolescents, and adults are now available according to age and gender, for right and lef common carotid arteries. 1. Introduction Te early detection of subclinical arterial damage is of value for individual cardiovascular risk assessment and identifca- tion of subjects with increased risk (vulnerable subjects) who could beneft from specifc preventive strategies [1]. In 1986, common carotid intima media thickness (CIMT) was frstly measured in in vitro studies of arteries from cadaveric donors and noninvasively in ambulatory healthy subjects [2]. Since then, arterial structure characterization through CIMT assessment was introduced in clinical practice and epidemiological investigations demonstrated the prog- nostic value of this noninvasive study. Common CIMT higher than 0.9 mm has been considered as a factor infuencing cardiovascular prognosis by the 2013 ESH/ESC Guidelines for the management of arterial hypertension [3]. Recently, Amato et al. reported that CIMT is an independent predictor of vascular events and should be included in cardiovascular risk models destined to population stratifcation and preven- tive strategies [4]. Interestingly, a CIMT score improved the Framingham risk score to predict coronary heart diseases events [4–6]. Also, a recent European consensus reported that increase of CIMT has shown to be marker of hypertension vascular damage and increased cardiovascular risk [5]. Since CIMT is relatively easy to evaluate, the clinical use allows the risk stratifcation and target organ damage assessment [5, 6]. Age and gender specifc percentiles for common CIMT were defned in large populations of healthy subjects and the infuence of cardiovascular risk factors (CRFs) was quantifed allowing comparative studies among groups with diferenti- ated risk profles [7]. Epidemiological studies also included pediatric research to characterize age-related CIMT changes Hindawi International Journal of Hypertension Volume 2018, Article ID 8086714, 13 pages https://doi.org/10.1155/2018/8086714