Acta Stomatologica Naissi Dec / Dec. 2015, Vol. 31, br./ num. 72str./p 1493-1503 Primljen/ Recived on : 02.06.2015. Revidiran/ Revised on : 04.09.2015. Prihvaćen/ Accepted on : 28.09.2015. PROMENE PLJUVAČKE KOD OSOBA SA BULOZNIM LIHEN PLANUSOM SALIVARY HUMORAL CHANGES IN ORAL BULLOUS LICHEN PLANUS Mirjana Popovska 1 , Ana Minovska 2 , Vera Radojkova-Nikolovska 1 , Ilijana Muratovska 1 , Biljana Kapuševska 1 , Pavlina Aleksova 1 , Spiro Spasovski 3 1 UNIVERZITET SV. ĆIRILA I METODIJA, STOMATOLOŠKI FAKULTET, 1000 SKOPJE, REPUBLIKA MAKEDONIJA 2 UNIVERZITET GOCE DELČEV, MEDICINSKI FAKULTET, 1000 ŠTIP, REPUBLIKA MAKEDONIJA 3 PRIVATNA STOMATOLOŠKA ORDINACIJA „FJOLLA MEDIKA”, 1000 SKOPJE, REPUBLIKA MAKEDONIJA 1 UNIVERSITY ST. CYRIL AND METHODIUS, FACULTY OF DENTISTRY, 1000 SKOPJE, REPUBLIC OF MACEDONIA 2 UNIVERSITYGOCEDELČEV, FACULTY OF MEDICINE, 1000 ŠTIP, REPUBLIC OF MACEDONIA 3 PRIVATE DENTAL OFFICE „FJOLLAMEDIKA”, 1000 SKOPJE, REPUBLIC OF MACEDONIA Sažetak Cilj: Cilj istraživanja bio je ispitivanje humoralnih mehanizama u pljuvački kod pacijenata sa buloznim lihen planusom u fazi egzacerbacije i remisije. Materijal i metod: Praćeno je devetnaest pacijenata sa oralnim buloznim lihen planusom. Pljuvačka je prikupljana u jutarnjim časovima, bez stimulacije, u količini 5-10 cm 3 . Određivanje imunoglobulina, C3 i C4 u pljuvački vršilo se primenom tehnike „microelis“. Cirkulišući imuni kompleksi u serumu i pljuvački određivani su PEG metodom. Dobijeni rezultati upoređivani su sa kontrolnom grupom i međusobno u fazi egzacerbacije i remisije. Rezultati su statistički obrađeni Studentovim „t“ - testom. Rezultati: Ispitivanja su pokazala da je količina IgA u pljuvački značajno smanjena , dok je količina IgG i IgM značajno uvećana. Vrednosti imunoglobulina A , G i M u fazi remisije značajno su povećane kod bolesnika u odnosu na kontrolnu grupu. Upoređivanjem pljuvačke u fazi egzacerbacije i remisije dobile su iste količine IgG u oba stadijumima bolesti , ali evidentno povišene vrednosti IgA i malo značajno povećanje vrednosti IgM. U kontrolnoj grupi i grupi pacijenata u fazi egzacerbacije i remisije takođe su povećane CIC vrednosti . Podaci ukazuju na visoko značajnu depresiju komponente C3 u fazi egzacerbacije, dok je u remisiji vidljivo malo značajno smanjenje. Komplement komponente C4 u fazi remisije opada u poređenju sa kontrolnom grupom. Zaključak: Postoji evidentno učešće pojedinih komponenti pljuvačke u patogenezi oralnog lihen planusa, ali konačna pozicija za prevlast humoralnih mehanizama u patogenezi buloznog lihen planusa još uvek ne postoji. Ključne riječi: bulozni oralni lihen planus, pljuvačka, imunoglobulini, komplement Abstract Background: To investigate the salivary humoral mechanisms in patients with bullous lichen planus, in the phases of exacerbation and remission. Material and Method: Nineteen patients with bullous oral lichen planus were followed. Saliva was collected in the morning without stimulation in the amount from 5-10 cm 2 . The determination of immunoglobulins, C3 and C4 in the saliva was performed using the micro-ELISA technique. The circulating immune complexes in the serum and saliva were determined by the PEG method. The results were compared with a control group and within the group in the phases of exacerbation and remission. The results were statistically processed by Student’s t - test . Results: Salivary IgA showed a significant decrease, whereas IgG and IgM significantly increased. The values of immunoglobulin A, G and M in the phase of remission were significantly increased compared with the control group. By comparing salivary immunoglobulins in the phases of exacerbation and remission, identical amounts of IgG in both stages of the disease were observed. However, considerably elevated values of IgA and slightly significant increase in the values of IgM were noted. CIC values in the control group and in patients’ group in the phases of exacerbation and remission were increased. Data suggest a highly significant depression of C3 component in the exacerbation phase, while in remission a slightly significant decrease was evident. Complement component C4 in the remission phase compared with a control group was declined. Conclusion: There is an evident involvement of certain saliva components in the pathogenesis of oral lichen planus, but the final predominance of humoral mechanisms in the pathogenesis of bullous lichen planus does not exist yet. Key words: bullous oral lichen planus, salivary immunoglobulins, complement. Address for correspondence: Mirjana Popovska , Prof, PhD, University St. Cyril and Methodius, Faculty of dentistry, MajkaTereza bb, 1000 Skopje, Republic of Macedonia, E-mail: popovskam2002@yahoo.com Tel:+38970519304 © 2015 Faculty of Medicine in Niš. Clinic of Dentistry in Niš. All rights reserved / © 2015. Medicinski fakultet Niš. Klinika za stomatologiju Niš. Sva prava zadržana. KLINIČKI RAD CLINICAL ARTICLE doi:10.5937/asn1572493P 1493