_____________________________________________________________________________________________________ *Corresponding author: E-mail: internationalpublications2011@gmail.com; Journal of Pharmaceutical Research International 32(48): 85-95, 2020; Article no.JPRI.65470 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Comparison of Metabolic Syndrome, Uric Acid and Leisure Time Physical Activity between Former Athletes and Non-Athlees Zayed M. Altowerqi 1,2* and Zainal Abidin Bin Zainuddin 2 1 Physical Education Department, Faculty of Education, Umm Al-Qura University, Makkah, Saudi Arabia. 2 Faculty of Social Sciences and Humanities, School of Education, University Technology Malaysia, Johor Bahru, Malaysia. Authors’ contributions This work was carried out in collaboration between both authors. Both authors were instrumental in the conception, research development and study design. Both authors read and gave final approval for the manuscript submission and publication. Article Information DOI: 10.9734/JPRI/2020/v32i4831128 Editor(s): (1) Dr. Ana Cláudia Coelho, University of Trás-os-Montes and Alto Douro, Portugal. Reviewers: (1) Liliana-Elisabeta RADU , “Alexandru Ioan Cuza” University of Iasi, Romania. (2) Alireza Mohtashami , Islamic Azad University, Iran. Complete Peer review History: http://www.sdiarticle4.com/review-history/65470 Received 25 November 2020 Accepted 02 February 2021 Published 09 February 2021 ABSTRACT This study aims to determine the prevalence of metabolic syndrome (MS), overweight and obesity, uric acid (UA), and leisure time physical activity (LTPA) among former athletes and non-athletes in the Kingdom of Saudi Arabia (KSA). Moreover, to determine the effects of previous high intensity training on MS risk factors, overweight and obesity, and UA. Seventy-five (75) former athletes and twenty-six (26) non-athletes, aged between 26 and 60 years old, participated in this study. Height, weight, waist circumference (WC), blood pressure (BP), and blood samples were collected by the researcher. LTPA was reported by participants. The study results showed that 38.61% of former athletes have MS and 17.82% of non-athletes have MS. The study also showed that 31.68% of former athletes were overweight and 26.73% were obese. However, the prevalence of overweight and obesity among non-athletes was 9.90%. 23.76% of former athletes had high level of UA, whereas 14.85% of non-athletes had high level of UA. According to the study findings 28% former athletes participated in high physical activity (PA), 38.67% in moderate PA, and 33.33% in low PA, Original Research Article