1 Cryptic amyloidogenic elements in the 3`-UTR of neurofilament genes trigger axonal neuropathy Adriana P. Rebelo 1 , Alexander J. Abrams 1 , Ellen Cottenie 2,3 , Alejandro Horga 2,3 , Michael Gonzalez 1 , Dana M. Bis 1 , Avencia Sanchez-Mejias 1 , Milena Pinto 1 , Elena Buglo 1 , Kasey Markel 5 , Jeffrey Prince 5 , Matilde Laura 2,3 , Henry Houlden 2,3,4 , Julian Blake 2,3 , Cathy Woodward 2,3 , Mary Sweeney 2,3 , Janice Holton 2,3 , Michael Hanna 2,3 , Julia E. Dallman 5 , Michaela Auer-Grumbach 6 , Mary M. Reilly 2,3* , Stephan Zuchner 1* 1. Dr. John T Macdonald Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA 2. MRC Centre for Neuromuscular Diseases, 3. Department of Molecular Neurosciences, 4. Neurogenetics Laboratory, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK 5. Department of Biology, University of Miami, Miami, FL 33146, USA 6. Department of Orthopaedics, Medical University Vienna, Vienna, Austria * These authors contributed equally Corresponding Author Dr. Stephan Zuchner, University of Miami Miller School of Medicine, Biomedical Research Building (BRB), Room 523, LC: M-860, 1501 NW 10th Avenue, Miami, FL 33136; USA; Email: szuchner@med.miami.edu