_____________________________________________________________________________________________________ *Corresponding author: E-mail: bhubonsingh@gmail.com; Chemical Science International Journal 26(2): 1-19, 2019; Article no.CSIJ.48127 ISSN: 2456-706X (Past name: American Chemical Science Journal, Past ISSN: 2249-0205) Synthesis, Characterization and DNA Binding Studies of (E)-1-((Pyridin-2-yl)methylidene) semicarbazide Mn(II), Co(II), Ni(II) and Cu(II) Complexes Oinam U-wang 1 , R. K. Bhubon Singh 1* , W. Bembee Devi 1 , U. Ibotomba Singh 1 , R. K. Bindiya Devi 1 , O. Bijeta Devi 1 , Ramina 1 , Th. Surchandra Singh 1 and Toka Swu 2 1 Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India. 2 Department of Chemistry, Pondicherry University, R.V. Nagar, Kalapet, Puducherry 605014, India. Authors’ contributions This work was carried out in collaboration among all authors. Author RKBS designed the study. Author OU performed the experiments. Authors OU, WBD, UIS, RKBD, OBD, Ramina and TSS performed literature survey and statistical analysis. All the authors wrote the protocol and first draft of the manuscript and managed the analyses of the study. Author TS collected X-ray diffraction data. All authors read and approved the final manuscript. Article Information DOI: 10.9734/CSJI/2019/v26i230091 Editor(s): (1) Dr. T. P. West, Professor, Department of Chemistry, Texas A&M University-Commerce, USA. Reviewers: (1) Rodica Olar, University of Bucharest, Romania. (2) Katalin Mészáros Szécsényi, University of Novi Sad, Serbia. Complete Peer review History: http://www.sdiarticle3.com/review-history/48127 Received 09 January 2019 Accepted 22 March 2019 Published 27 March 2019 ABSTRACT (E)-1-((pyridin-2-yl)methylidene)semicarbazide (PMSC) complexes of [Mn(PMSC) 2 ]Cl 2 (1), [Co(PMSC) 2 ]Cl 2 (2), [Ni(PMSC) 2 ]Cl 2 .5H 2 O (3), and [Cu(PMSC)(H 2 O)]Cl 2 (4) have been synthesized and characterized by different spectroscopic techniques, EPR, magnetic susceptibility and thermal stability measurements. Complex 3 crystallizes as octahedral coordination complex in monoclinic crystal system. Complexes 1 and 2 have been found to have octahedral geometries and 4 to have square planar geometry. The complexes were found to be groove binding to calf-thymus DNA. Original Research Article