Image Article Trends in Cancer Research and Chemotherapy Trends Cancer Res Chemother, 2018 doi: 10.15761/TCRC.1000112 Volume 1(2): 1-2 ISSN: 2517-7206 Immunoscintigraphy with 99m Tc-14F7 and 99m Tc- Nimotuzumab in patients with non-small cell lung cancer Yamilé Peña 1 *, Tania Crombet 2 , Alex Vergara 1 , Juan F Batista 1 , Leonel A Torres 1 and Anais Prats 2 1 Direction for Clinical Research. Isotope Center. Havana. Cuba 2 Center of Molecular Immunology. Havana. Cuba Abstract Te immunoscintigraphy is a non-invasive technique with high specifcity. Te technique provides information on the location of the tumor and its metastases, detects specifc biomarkers on the cell surface of tumors, characterizing it by establishing its biology and phenotype. It also evaluates the response to the treatment that is applied, and allows performing a personalized targeted therapy. Te authors show the imagines of two patients with non-small cell lung cancer after administration of the 99m Tc-14F7 and 99m Tc-Nimotuzumab. Te tumors showed high expression of specifc antigens. *Correspondence to: Yamile Peña Quián, Direction for Clinical Research. Isotope Center, Kohly, Playa, Havana, P. O. Box 11300, Cuba, Tel: (53 7) 202 3763; Fax: (53 7) 204 3298; E-mail: yamilepq@infomed.sld.cu Key words: immunoscintigraphy, cancer, monoclonal antibody, 99mTc, Nimotuzumab, 14F7 Received: July 12, 2018; Accepted: August 24, 2018; Published: August 28, 2018 Figure 1. A 66-years-old man, tumor in the upper lobe of left lung, biopsy reported anon- small cell lung cancer (NSCLC) A) Computed tomography: Tomogram and coronal slices of the thorax show tumor in the upper lobe of the lef lung, fuid accumulated in the pleural cavity pleural and destruction in the nearby costal arches. B) Immunoscintigraphy: Whole-body scans, anterior views, 4 and 24 hours afer the intravenous administration of 1110 MBq (30mCi) of 99m Tc-labeled Nimotuzumab. Some regions of physiological uptake were masked. Intense uptake of the radioimmunoconjugate in the tumour was beingobserved from the frst 4 hours. Uptake persisted at 24 hours later. Te images helped to locate the tumour and evidence the expression of specifc receptors. C) Immunoscintigraphy: SPECT of thorax, (coronal and transverse slices). Te picture shows the lung tumor accurately. In the 4-hour views, the lack of uptake of the radioimmunoconjugate below the tumor was observed as consequence of the pleural efusion. Nimotuzumab (hR3) is a humanized IgG1 monoclonal antibody directed against epidermal growth factor receptor (EGFr) [1-4]. It has potent anti-proliferative, antiangiogenic, and pro-apoptotic efects in vitro and in vivo. Te increment in the concentrations of the EGF in the serum identifes the patients with cancer of lung that will beneft of the therapeutic vaccine of EGF [5]. immunoscintigraphy with 99m Tc-