February 2020 · Volume 9 · Issue 2 Page 861 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Gaughran J et al. Int J Reprod Contracept Obstet Gynecol. 2020 Feb;9(2):861-865 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Case Report Juvenile granulosa cell tumour in the third trimester of pregnancy Jonathan Gaughran 1 *, Argha Datta 2 , Judith Hamilton 1 , Tom Holland 1 , Ahmad Sayasneh 1,3 INTRODUCTION A granulosa cell tumour of the ovary (GCT) is a rare malignancy that arises from the sex-cord stromal cells. They account for 2-5% of ovarian cancers diagnosed worldwide. 1 The juvenile subtype, which occurs in premenerchal girls and younger women, is rarer still, accounting for 0.1% of all ovarian tumours. 2 Juvenile GCTs most commonly present as a large pelvic mass and/or pubertal or menstrual irregularities due to the tumour secreting oestrogen, follicle‐regulating protein, folliculin and inhibin. 3 This case report described a case of Juvenile GCT detected incidentally during routine antenatal care. CASE REPORT A 26-year-old nulliparous lady attended a tertiary hospital in her first pregnancy for antenatal care. She had no significant medical or surgical history; BMI was 31. Routine dating ultrasounds scan at 13 weeks gestation revealed an incidental fundal intramural fibroid measuring 88 × 77 × 61 mm. Combined screening was low risk for chromosomal abnormalities. As per the local hospital protocol the ovaries were not assessed at 13 weeks. Figure 1: Trans-abdominal ultrasound transverse section of right ovary at 20 weeks gestation. Enlarged polycystic appearance with moderate peripheral doppler flow. ABSTRACT This case report describes the rare finding of a granulosa cell tumour in the third trimester of pregnancy. The presentation, investigation, management, histopathological findings and subsequent follow up are detailed. The difficulties associated with such diagnoses in pregnancy are explored. Keywords: Cancer, Granulosa, Juvenile, Ovary, Ovarian, Pregnancy DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20200395 1 Department Gynecology, Gynaecology Department. Guy’s and St Thomas’ Hospitals, London, United Kingdom 2 Medical Student King’s College London Medical School, London, United Kingdom 3 School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, Guy’s and St Thomas’ Hospitals, London, United Kingdom Received: 10 April 2019 Revised: 23 December 2019 Accepted: 27 December 2019 *Correspondence: Mr. Jonathan Gaughran, E-mail: jonathan.gaughran@gstt.nhs.uk Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.