leading to the conversion of fibrin from fibrinogen, thereby aiding clot
formation.
FLOSEAL was first used during laparoscopy for a diaphragmatic
hernia repair and has since been used effectively in elective gyneco-
logical procedures such as myomectomy, ovarian cystectomy [4],
and treatment of endometriosis. It should not be considered as a
first-line agent since the majority of hemorrhage can be controlled
with meticulous surgical technique. However, if other laparoscopic
surgical measures, including suturing, bipolar electrocautery, and
the harmonic scalpel have failed, then it is an extremely useful sec-
ondary adjunct.
Conflict of interest
The authors have no conflicts of interest to declare.
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0020-7292/$ – see front matter © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
doi:10.1016/j.ijgo.2011.11.003
Effect of concomitant oophorectomy on the perioperative outcomes
of laparoscopic hysterectomy☆
Keisha Jones, Oz Harmanli ⁎, Cara A. Robinson, Sertac Esin, Ayse Citil, Alexander Knee
Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, Springfield, MA, USA
article info
Article history:
Received 26 October 2011
Received in revised form 29 November 2011
Accepted 13 December 2011
Keywords:
Laparoscopic hysterectomy
Oophorectomy
Perioperative complications
Prophylactic oophorectomy
☆ Paper presented as an oral poster at the 37th Annual Scientific Meeting of the
Society of Gynecologic Surgeons in San Antonio, Texas, USA, held April 11–13,
2011.
⁎ Corresponding author at: Urogynecology and Pelvic Surgery, Baystate Medical
Center, Tufts University School of Medicine, 759 Chestnut Street, S1680, Springfield,
MA 01199, USA. Tel.: +1 413 795 5608.
E-mail address: oz.harmanli@bhs.org (O. Harmanli).
The dilemma concerning elective oophorectomy continues to
resurface as hysterectomy remains the most common major gyne-
cologic surgery performed in the USA [1]. While the pendulum con-
tinues to swing, there remains a paucity of information about the
surgical outcomes of this practice. The objective of the present
study was to assess whether concomitant adnexal removal at the
time of laparoscopic hysterectomy has an impact on perioperative
outcomes.
This is an ancillary analysis from a database created at Baystate
Medical Center, USA. The methods have been described previously
[2]. This was a retrospective cohort, including all total and supra-
cervical laparoscopic hysterectomies performed for benign
conditions between November 1999 and August 2008. Patients
with pelvic pain, endometriosis, pelvic mass, or endometrial
hyperplasia were excluded. Patients were categorized based
on the presence or absence of elective concomitant adnexal
removal.
After comparing baseline characteristics, comorbid conditions,
and indications for surgery, perioperative outcomes were evaluat-
ed including operating time, serious complications, and conversion
to laparotomy. Of the 612 eligible cases, 249 (40.7%) included con-
comitant oophorectomy. As expected, patients who underwent ad-
nexal removal were slightly older (42±5 vs 47±7 years) and
more likely to be postmenopausal. This difference did not seem to
be clinically significant as a small difference in age would not likely
translate into a clinical effect. The hysterectomy only group was
more likely to have menorrhagia as the surgical indication and
less likely to have pelvic organ prolapse. There were no significant
differences in operating time ≥ 200 minutes, change in hemoglobin
≥ 2.5 g/dL, febrile morbidity, urinary tract injury, or serious
complications.
Conversion to laparotomy was significantly increased in women
undergoing concomitant adnexal removal compared with hyster-
ectomy only (11.1% vs 3.3%, Adjusted Relative Risk 3.34; 95% CI,
1.58–7.08; Table 1). The magnitude of these results varied by
prior adnexal surgery in the patient and surgeons’ volume of
work. Unadjusted estimates suggest that length of hospital stay
greater than 24 hours was an increased risk for those with concom-
itant adnexal removal (RR 1.60; 95% CI, 1.14–2.26; Table 1). Strati-
fied estimates further indicate that, after adjusting, increased risk
resides among patients whose surgery was performed by surgeons
with a low volume of work.
This study did not show an increased risk of complications
when elective adnexal removal is performed with laparoscopic
hysterectomy. Even after adjustment, there was an increased
risk of conversion to laparotomy when hysterectomy was
conducted with concomitant adnexal removal compared with
hysterectomy alone. The present study provides clinicians with
valuable information about the short-term effects of combining
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