Integrated system for quantitative analysis of coronary plaque via data fusion of biplane angiography and intravascular ultrasound Mark E. Olszewski a, * , Andreas Wahle a , Rube ´n Medina a,b , Steven C. Mitchell a , Milan Sonka a a Department of Electrical and Computer Engineering, The University of Iowa, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242-1527, USA b Grupo de Ingenierı ´a Biome ´dica (GIBULA), Universidad de Los Andes, Me ´rida 5101, Venezuela Received 13 March 2003; received in revised form 13 March 2003; accepted 17 March 2003 Abstract This paper describes an analysis system that integrates our previously developed automated data fusion methodology for the geometrically correct reconstruction of coronary arteries from intravascular ultrasound (IVUS) and X-ray angiography with postprocessing and data management modules. The system further incorporates methods for the analysis of computational hemodynamics and calculates morphological indices for the description of coronary plaque. Data management is based on well-defined standards, and the overall design is meant to facilitate employment of developed methods in clinical trials. D 2003 Elsevier Science B.V. and CARS. All rights reserved. Keywords: Data fusion; Biplane angiography; Intravascular ultrasound 1. Introduction Clinical prognosis for patients with coronary atherosclerosis is directly related to the progression or regression of the disease. Currently, the preferred imaging modalities for the assessment of coronary artery disease are X-ray angiography and intravascular 0531-5131/03 D 2003 Elsevier Science B.V. and CARS. All rights reserved. doi:10.1016/S0531-5131(03)00277-2 * Corresponding author. Tel.: +1-319-335-5198; fax: +1-319-335-6028. E-mail address: mark-olszewski@uiowa.edu (M.E. Olszewski). URL: http://www.engineering.uiowa.edu/folszewsk. International Congress Series 1256 (2003) 1117– 1122