Research Article Camelina sativa Methanolic and Ethanolic Extract Potential in Alleviating Oxidative Stress, Memory Deficits, and Affective Impairments in Stress Exposure-Based Irritable Bowel Syndrome Mouse Models Roxana O. Cojocariu, 1 Ioana-Miruna Balmus, 1,2 Radu Lefter, 3 Luminita Hritcu, 4 Daniela C. Ababei, 5 Alin Ciobica , 1 Simona Copaci, 6 Silvia E. L. Mot, 7 Lucian Copolovici , 8 Dana M. Copolovici , 8 and Stefana Jurcoane 6,9 1 Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, B-dul Carol I, No. 11 Iasi, Romania 2 Department of Interdisciplinary Research in Science, Alexandru Ioan Cuza University of Iasi, Carol I Avenue, No. 11, Iasi 700506, Romania 3 Romanian Academy, Center of Biomedical Research, B-dul Carol I, No. 8 Iasi, Romania 4 Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine “Ion Ionescu de la Brad” of Iasi, 3rd Mihail Sadoveanu Alley Iasi 700490, Romania 5 “Grigore T. Popa” University of Medicine and Pharmacy, Universitatii Street, No. 16, 700115 Iasi, Romania 6 Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine from Bucharest, Bd. Marasti, No. 59, 011464 Bucharest, Romania 7 Doctoral School of Biomedical Sciences, University of Oradea, Universității Str., No 1, 410087 Oradea, Romania 8 Faculty of Food Engineering, Tourism and Environmental Protection; Institute for Research, Development and Innovation in Technical and Natural Sciences, “Aurel Vlaicu” University of Arad, Elena Dragoi St. no 2, 310330 Arad, Romania 9 Academy of Romanian Scientists, Splaiul Independentei, No 54, Sector 5, 050094 Bucharest, Romania Correspondence should be addressed to Alin Ciobica; alin.ciobica@uaic.ro and Dana M. Copolovici; dana.copolovici@uav.ro Received 27 July 2020; Revised 30 November 2020; Accepted 8 December 2020; Published 24 December 2020 Academic Editor: Antonello Lorenzini Copyright © 2020 Roxana O. Cojocariu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Camelina sativa is mainly used as an oilseed crop; its edible oil is being also used as a traditional home remedy for the treatment of ulcers, wounds, and eye inflammations, due to the antioxidant activities. In the present study, the chemically characterized alcoholic extracts of Camelina sativa var. Madalina defatted seeds (5 g/kg body weight p.o., suspended in CMC-Na 0.1%) were administered to stress-induced animal models of irritable bowel syndrome (based on combinations of contention stress and multifactorial stress and maternal stress) and evaluated for the behavioural (short-term memory by the Y maze test, the anxious behaviour using the elevated plus maze test, and the antidepressant effect using the forced swimming test) and brain and bowel tissue oxidative status (superoxide dismutase and glutathione peroxidase enzymes activities and malondialdehyde and total soluble protein levels) improving effects. According to the chemical characterization, the extracts were rich in sinapine, glucosinolates, and flavonol glycosides. Moreover, this study showed the beneficial effects of Camelina sativa seed methanolic and ethanolic extracts on the behaviour and brain and bowel tissues oxidative stress status of stress exposure-based IBS mouse models. Despite the slight differences in the chemical composition of the methanolic and ethanolic extracts, the results suggested that the Camelina sativa extracts could reverse the short-term memory impairments caused by stress exposure and also could decrease the intensity and frequency of the anxiety and depressive-like behaviours observed in the stress-exposed animal models of IBS. Furthermore, the Camelina sativa extracts showed a significant effect on the oxidative stress markers in the brain and bowel tissues of the studied animal model by decreasing the superoxide dismutase activity and increasing the glutathione peroxidase activity. However, the results suggested that the extracts could also increase lipid peroxidation in bowel tissues. In this way, this Hindawi Oxidative Medicine and Cellular Longevity Volume 2020, Article ID 9510305, 20 pages https://doi.org/10.1155/2020/9510305