Escape through an unstable limit cycle: Resonant activation Bidhan Chandra Bag * and Chin-Kun Hu Institute of Physics, Academica Sinica, Taipei 11529, Taiwan Received 13 April 2006; published 26 June 2006 We consider a Brownian particle acted on by a linear conservative force, a nonlinear frictional force, and multiplicative colored and additive white noises; the frictional force can be negative when the external energy supply is large enough. We numerically calculate the mean first passage time MFPTfor the particle to escape from an unstable limit cycle and find resonant activation, i.e., the MFPT first decreases, followed by a rise after passing through a minimum with increasing noise correlation time for a fixed noise variance. For fixed noise strength of the multiplicative noise the MFPT increases linearly with . This is in sharp contrast to the case of fluctuations of nonlinear potentials, in which the MFPT first increases nonlinearly before reaching a limiting value. Our model could be useful for understanding some biological processes. DOI: 10.1103/PhysRevE.73.061107 PACS numbers: 05.40.Jc, 05.45.-a, 05.20.-y, 05.70.Ln The processes of noise-driven escape of particles over po- tential barriers, i.e., the well-known Kramers’ problem 1, are ubiquitous in a wide variety of physical, chemical, and biological contexts 2. Kramers considered a model Brown- ian particle trapped in a one-dimensional well representing the reactant state, which is separated by a barrier of finite height from a deeper well, signifying the product state. The particle was supposed to be immersed in a medium such that the medium exerts a frictional force on the particle but ther- mally activates it so that the particle may gain enough energy to cross the barrier. Over several decades the model and many of its variants have served as standard paradigms in various problems of physical and chemical kinetics to under- stand the decay rate of metastable systems in the over- damped and underdamped limits 3, the effect of anharmo- nicities 4, the role of the relaxing bath 5, the signature of non-Markovian effects 6, and quantum and semiclassical corrections to the classical rate and related similar aspects 7. The vast body of literature has been the subject of sev- eral reviews 2,8. In the majority of these studies the focus lies on the competing attractors of the dynamical system, which are separated by a separatrix containing a saddle point. However, models where the separatrix is instead an unstable limit cycle often arise in the context of chemical reactions constrained to occur far from a equilibrium 9. The rate of escape through the unstable limit cycle in the weak noise limit has been studied 10and noise-driven transitions in models with an unstable limit cycle can be found in Ref. 11. Most of the works mentioned above have considered the static barrier. However, a surge of fresh interest in this topic was triggered, not long ago, by Doering and Gadoua 12 who studied how the interwell mean first passage time MFPTof a Brownian particle in a bistable potential de- pends on the correlation time of the barrier fluctuations. They observed that this dependence may be nonmonotonic and called it resonant activation RA. This interesting phe- nomenon 12has been further investigated 13–19. In the present paper we examine a related issue. We show that the phenomenon of RA appears in the problem of escape through an unstable limit cycle in the presence of multiplicative col- ored and additive white noises. Although traditionally RA appears due to fluctuations in a nonlinear potential, the present analysis suggests that it may be observed even in the presence of a linear potential as a result of strange behavior of the limit cycle. The limit cycle is a conspicuous feature in a variety of models in biology and chemistry that deal with situations far from thermal equilibrium. On the other hand, in Refs. 17,19it was emphasized that “far from equilibrium” is one of the necessary conditions for the RA phenomenon. To start with, we consider a simple model defined by v ˙ =- aq + bv 2 -1v + qt+ t, 1 where q and v q ˙ represent the coordinate and the velocity of the Brownian particle, and tand tare Gaussian colored and white noises, respectively. In general, we ex- press the thermal fluctuation of the system as additive noise and the effect of the external environmental fluctuation on the system as multiplicative noise. Thus tand tin Eq. 1correspond to internal thermal noise and external noise, respectively. In a complex system multiplicative noise is very relevant and it makes the system far from equilibrium. The two noises are characterized by the relations t =0, t =0, tt' = D 0 e -|t-t'|/ , 2 tt' =2Dt - t'. 3 Here D 0 and are the strength and correlation time of the multiplicative noise; D is the strength of the additive white noise. Equation 2shows that in Eq. 1is the Ornstein- *On leave from Department of Chemistry, Visva-Bharati, Santini- ketan, India. Corresponding author. Electronic address: huck@phys.sinica.edu.tw PHYSICAL REVIEW E 73, 061107 2006 1539-3755/2006/736/0611074©2006 The American Physical Society 061107-1