Efektivitas Vitamin D terhadap CD 4 ODHIV Ninuk Dian Kurniawati 1 , Ade Yuvida, Mutiara Handasari, Sabrina Rahmatillah, Titis Roedhotul, Nur Alfiyyatul Laila, Nida Harosa. Kelompok 2 Keperawatan HIV AIDS 1 Faculty of Nursing, Universitas Airlangga Corresponding Author: Ninuk Dian .K. Has, email: ninuk.dk@fkp.unair.ac.id ABSTRACT Introduction: HIV (Human Immunodeficiency Virus) is a typical lymphotropic retrovirus that infects cells of the immune system, destroys or destroys specific white blood cells called T- helper lymphocytes or T4 factor carrier lymphocytes (CD4). Vitamin D is a major regulator of host defense against infection by activating genes and pathways that enhance acquired innate immunity. A study in Uganda reported that the CD4 cell count of HIV patients with vitamin D deficiency was consistently lower than that of HIV patients with normal vitamin D levels. This study also stated that HIV patients with low vitamin D levels had lower survival rates than other HIV patients. Method: Literature review is a method used to collect data or sources related to a particular topic that can be obtained from various sources such as journals, books, internet and other libraries. The strategy used to find articles using PEOS. Exposure related to this study is the effect of vitamin D on people living with HIV. The exclusion criteria consisted of non-people living with HIV/AIDS with the topic not focusing on administering vitamin D therapy to PLWHA. Journals or articles published in 2016 and above use Indonesian and English. Using The Joanna Brigg Institute (JBI) for several types of studies randomized control trial, cross sectional study, retrospective cohort study, and prospective cohort study. Results : HIV patients suffer from vitamin D deficiency which causes the infection rate to increase. Vitamin D is very effective against the immunity of HIV patients, especially vitamin D3. Vitamin D can function to increase the immunity of HIV patients who are in the healing period after being exposed to the disease. HIV patients who regularly consume vitamin D, recover 3 times faster than patients who do not take vitamin D. Discussion: Active vitamin D has a significant immunomodulatory effect as an important determinant of CD4 effector T cell differentiation. Vitamin D deficiency contributes to the pathogenesis of HIV infection by interfering with innate and adaptive immune responses. Vitamin D has strong immunomodulatory and antimicrobial effects in HIV infection. Keywords : Vitamin D, HIV/AIDS ABSTRAK Pendahuluan : HIV (Human Immunodeficiency Virus) merupakan retrovirus bersifat limfrotropik khas yang menginfeksi sel-sel dari system kekebalan tubuh, menghancurkan atau merusak sel darah putih spesifik yang disebut limfosit T-helper atau limfosit pembawa faktor T4 (CD4). Vitamin D merupakan pengatur utama pertahanan host melawan infeksi dengan mengaktifkan gen dan jalur yang meningkatkan imunitas alamiah yang di dapat. Penelitian di Uganda melaporkan jumlah CD4 pasien HIV dengan defisiensi vitamin D secara persisten lebih rendah dibandingkan pasien HIV dengan kadar vitamin D normal. Penelitian ini juga menyatakan bahwa pasien HIV dengan kadar vitamin D rendah memiliki angka ketahanan hidup lebih rendah disbanding dengan pasien HIV lainnya. Metode : Literature review adalah cara yang dipakai untuk mengumpulkan data atau sumber yang berhubungan pada sebuah topik tertentu yang bisa didapat dari berbagai sumber seperti jurnal, buku, internet dan pustaka lain.