UHOD Number: 1 Volume: 20 Year: 2010 55 Recurrent Myofibrosarcoma of the Sinonasal Tract Treated with Postoperative Radiation Therapy Gonca H. USLU 1 , Erkan TOPKAN 2 , Safak ERSOZ 3 , A. Umit ISIK 4 1 Karadeniz Technical University Faculty of Medicine, Department of Radiation Oncology, Trabzon 2 Baskent University Faculty of Medicine, Department of Radiation Oncology, Adana 3 Karadeniz Technical University Faculty of Medicine, Department of Pathology, Trabzon 4 Karadeniz Technical University Faculty of Medicine, Department of Ear-Nose and Throat Diseases, Trabzon, TURKEY ABSTRACT Myofibrosarcomas (MFSs) of the sinonasal tract are exceedingly rare tumors in adults. The principle treatment of MFS of the head and neck is surgical. However, aggressive surgery is not only debilitating, functionally and cosmetically, but tumor free margins are often difficult to obtain because of the local anatomy, and recurrence following surgery is likely. Here we report on a 64-year-old female patient who had a recurrence of an MFS of the sinonasal tract, despite prior aggressive surgery. The recurrence was successfully treated with a partial tumor resection followed by radiation therapy. To our knowledge, this is the second reported case of an MFS originating from the sinonasal tract in an adult, and the first treated with postopera- tive radiation therapy. This case indicates that postoperative radiation therapy may be beneficial in local disease control in such patients. However, more experience is needed to determine the efficacy of this therapeutic approach. Keywords: Myofibrosarcoma, Sinonasal tract, Recurrence, Radiation therapy ÖZET Postoperatif Radyoterapi ile Tedavi Edilmifl Sinonazal Reküren Myofibrosarkom Sinonazal bölge miyofibrosarkomu eriflkin yaflta oldukça nadir görülen bir tümör olup daha önce rapor edilmifl sadece bir vaka bulunmaktad›r. Bafl-boyun miyofibrosarkomlar›n›n güncel tedavisi tümörün cerrahi olarak ç›kar›lmas›d›r. Ancak, tümörün yerleflim yeri nedeniyle cerrahi bir yandan fonksiyonel ve kozmetik olarak a¤›r hasarlara sebebiyet verebilmekte, öte yandan negatif cerrahi s›n›r elde edilmesi oldukça zor olmakta ve dolay›s›yla hastal›k nüksüne s›kl›kla rastlanmaktad›r. Literatüre katk›da bulunabilmek amac›yla agresif cerrahi sonras› lokal nüks gösteren ve parsiyel cerrahiyi takiben radyoterapi uygulanan bir di¤er primer sinonazal miyofibrosarkomu olgusu takdim edilmifltir. Bildi¤imiz kadar›yla bu olgu eriflkin yaflta tespit edilmifl ikinci sinonazal bölge miyofibrosarkomu olup ayn› zamanda literatürde postoperatif radyoterapiyle baflar›l› bir flekilde tedavi edilmifl ilk olgudur. Bu sonuç postoperatif radyote-rapinin bu hastal›k gurubunda lokal kontrolün sa¤lanmas›nda etkin bir yön- tem olabilece¤ini iflaret etmektedir. Anahtar Kelimeler: Miyofibrosarkoma, Lokal nüks, Sinonazal bölge, Radyoterapi ULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI CASE REPORT International Journal of Hematology and Oncology