S1 Supporting Information Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening Renato Ferreira de Freitas † *, Mohammad S. Eram † , David Smil † , Magdalena M. Szewczyk † , Steven Kennedy † , Peter J. Brown † , Vijayaratnam Santhakumar † , Dalia Barsyte-Lovejoy † , Cheryl H. Arrowsmith †§ , Masoud Vedadi †‡ , Matthieu Schapira †‡ * † Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada § Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada ‡ Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada *Correspondence should be addressed to renato.freitas@utoronto.ca or mvedadi@utoronto.ca or matthieu.schapira@utoronto.ca Table of Contents I. Molecular dynamics simulation II. Chemistry III. Figures S1-S6 IV. References